Anti-BIT1 Rabbit Polyclonal Antibody
Anti-BIT1 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB113740 |
| Size | ：100 uL |
| Protein full name | ：Peptidyl-tRNA hydrolase 2, mitochondrial |
| Synonym | ：BIT1, CGI-147, peptidyl tRNA hydrolase 2, PTH 2, PTH2, PTRH2 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse BIT1 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：20 kDa |
| Observed MW. | ：18 kDa |
| Uniprot ID | ：Q9Y3E5 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1: 300-1: 600 |
K562, Raji, HepG2 |
Description
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators.
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Western blot analysis of BIT1 (GB113740) at dilution of 1: 600 |
Aliases for BIT1 Gene
- GeneCards Symbol: PTRH2 2
- Peptidyl-TRNA Hydrolase 2 2 3 5
- BIT1 2 3 4 5
- PTH2 2 3 4 5
- CGI-147 2 3 5
- CFAP37 2 3 5
- Cilia And Flagella Associated Protein 37 2 3
- Peptidyl-TRNA Hydrolase 2, Mitochondrial 3 4
- Bcl-2 Inhibitor Of Transcription 1 3 4
- EC 3.1.1.29 4 48
- PTH 2 3 4
- Bcl-2 Inhibitor Of Transcription 2
- IMNEPD 3
- PTH 3