Anti Human PPAR gamma common mouse monoclonal antibody (A3409A)

Product#: PP-A3409A-00
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Anti Human PPAR gamma common mouse monoclonal antibody (A3409A)
PPAR gamma: Peroxisome Proliferator-Activated Receptor gamma


General information 

Cat. No. :PP-A3409A-00
Size 100 ul
Antigen Species Human    
Host Species Mouse
Cross Reactivity :Human/ Mouse/ Rat 
Purification Ammonium sulfate fractionation.
Clone No :A3409A
Lot. A-1
Concentration 1 mg/mL
Ig Class G2a
Nomenclature NR1C3
Application   ELISA : 12ng/mL
Western Blot : 1 ug/mL
:Immunohistochemistry : 10μg/mL
Specificity This antibody specifically recognizes human PPAR gamma1 and 2 and cross reacts with mouse and
    rat PPAR gamma1 and 2. This antibody does not recognize human PPAR alpha and delta.
Storage Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots.
    Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended.
Form Physiological saline with 0.1% NaN3 as a preservative
Genbank L40904


Description


Peroxisome proliferator-activated receptor gamma (PPARg; NR1C3) is a member of orphan nuclear receptor. Oxidized metabolites of linoleic acid, 9- hydroxyctadienoic acid (9-HODE) and 13-HODE are activators and ligands of PPARg. PPARg is expressed in white adipose tissue, intestinal mucosa, colon, spleen, monocytes, macrophages, retina, cartilage, osteoclast and skeletal muscle. PPARg plays important roles in lipid and glucose metabolism, and have been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three members were called PPARa, b, g. Three N-terminal isoforms, called g1, g2 and g3, are known to arise by alternative splicing and promoter usage from the PPARg gene. RXR is an obligate partner for PPAR.

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Origin

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human PPAR gamma1 (3-108 aa) .

Note
Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.
 

Reference 

  1. Tanaka T, et al . J Atheroscler Thromb, 9(5): 233-241, 2002.



Aliases for PPARG Gene

  • Peroxisome Proliferator Activated Receptor Gamma 2 3 5
  • Peroxisome Proliferator-Activated Receptor Gamma 2 3 4
  • NR1C3 2 3 4
  • Nuclear Receptor Subfamily 1 Group C Member 3 3 4
  • PPAR-Gamma 3 4
  • PPARgamma 2 3
  • PPARG1 2 3
  • PPARG2 2 3
  • Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1 3
  • Peroxisome Proliferator-Activated Receptor-Gamma Splicing 3
  • Peroxisome Proliferative Activated Receptor, Gamma 2
  • Peroxisome Proliferator-Activated Receptor-Gamma 5 3
  • PPARG5 3
  • CIMT1 3
  • PPARG 5
  • GLM1 3

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