Anti Human PPAR gamma 2 mouse monoclonal antibody (K8450B)
Anti Human PPAR gamma 2 mouse monoclonal antibody (K8450B)
PPAR gamma: Peroxisome Proliferator-Activated Receptor gamma
General information
| Cat. No. | ：FNK-PP-K8450B-00 |
| Size | ：100 ul |
| Antigen Species | ：Human |
| Host Species | ：Mouse |
| Cross Reactivity | ：Human/ Mouse |
| Purification | ：Ammonium sulfate fractionation. |
| Clone No | ：K8450B |
| Lot. | ：A-2 |
| Concentration | ：1 mg/mL |
| Ig Class | ：G2a |
| Nomenclature | ：NR1C3 |
| Application | ：ELISA : 0.1 ug/mL ：Western Blot : 2 ug/mL ：Non reducing Western Blot 4 ug/mL ：Supershift Assay: 100 ug/mL |
| Specificity | ：This antibody specifically recognizes human PPAR gamma2 and cross reacts with mouse PPAR gamma 2. This antibody does not recognize human PPAR gamma1, alpha and delta. Not yet tested in other species. |
| Storage | ：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended. |
| Form | ：Physiological saline with 0.1% NaN3 as a preservative |
| Genbank | ：U79012 |
Description
Peroxisome proliferator-activated receptor gamma (PPARg; NR1C3) is a member of orphan nuclear receptor. Oxidized metabolites of linoleic acid, 9- hydroxyctadienoic acid (9-HODE) and 13-HODE are activators and ligands of PPARg. PPARg is expressed in white adipose tissue, intestinal mucosa, colon, spleen, monocytes, macrophages, retina, cartilage, osteoclast and skeletal muscle. PPARg plays important roles in lipid and glucose metabolism, and have been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three members were called PPARa, b, g. Three N-terminal isoforms, called g1, g2 and g3, are known to arise by alternative splicing and promoter usage from the PPARg gene. RXR is an obligate partner for PPAR.
Origin
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human PPAR gamma2 (2-28 aa).
Note
Reference
- Tanaka T, et al . J Atheroscler Thromb, 9(5): 233-241, 2002.
Aliases for PPARG Gene
- Peroxisome Proliferator Activated Receptor Gamma 2 3 5
- Peroxisome Proliferator-Activated Receptor Gamma 2 3 4
- NR1C3 2 3 4
- Nuclear Receptor Subfamily 1 Group C Member 3 3 4
- PPAR-Gamma 3 4
- PPARgamma 2 3
- PPARG1 2 3
- PPARG2 2 3
- Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1 3
- Peroxisome Proliferator-Activated Receptor-Gamma Splicing 3
- Peroxisome Proliferative Activated Receptor, Gamma 2
- Peroxisome Proliferator-Activated Receptor-Gamma 5 3
- PPARG5 3
- CIMT1 3
- PPARG 5
- GLM1 3
