Amidepsine D, 5 mg
Product#: FNK-BLK-0314-5mg
$475.59
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Amidepsine D
Cat No: FNK-BLK-0314-5mg
Product ID and Size
| Cat No. | Description | Size | Link |
| FNK-BLK-0314-100ug | Amidepsine D | 100μg |  |
| FNK-BLK-0314-1mg | Amidepsine D | 1mg | |
| FNK-BLK-0314-5mg | Amidepsine D | 5mg | |
Description
Biological activity: Diacylglycerol Acyltransferase (DGAT) is exclusively involved in triacetylglycerol formation. Excessive accumulation of triacetylglycerol can cause fatty liver, obesity and hypertriglyceridemia, which lead to serious diseases such as atherosclerosis, diabetes and metabolic disorders. Therefore, DGAT is target for pharmaceutical inhibition. The inhibitory activity of DGAT was tested by an enzyme assay using rat liver microsomes and by a using RAJI cells. Amidepsines are the first DGAT inhibitors.
Origin: Humcola sp. FO-2942
CAS Registry Number: 79786-34-8
CA Index Name: 4-[[4-[(2,4-Dimethoxy-6- methylbenzoyl)oxy]-2-hydroxy-6- methylbenzoyl]oxy]-2-hydroxy-6- methylbenzoic Acid
Appearance: Slightly pink white powder
Molecular Formula/ Weight: C26H24O10=496.48
Melting Point: 168-169°C
Purity: >95.0% by HPLC
Solubility: Sol. in Methanol, Benzene, EtOAc Inso. in water, Hexane
Handling and Storage: Store at -20℃.
References:
- H.Tomoda et al., J.Antibiot., 48, 937 (1995).
- H.Tomoda et al., J.Antibiot., 48, 942 (1995).
- H.Tomoda et al., J.Antibiot., 49, 929 (1996).
- J.A.Elix et al., Aust.J. Chem., 34, 1757 (1981).
