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Packing Unit
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10 tests
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50 tests
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200 tests
ApoFlamma® H 774
Cat. No. List below
Description
Specifications
- Fluorophore: Flamma® 774
- Application: Apoptotic cell imaging
- Excitation/Emission Max.(nm): 774/806 nm
- Molecular weight: 1802.12 g/mol
- Appearance: Blue Solid
- Storage conditions: 4 ℃, protect from light
Table 1. ApoFlamma® H series list
| Quick link (Cat.#) | Series | Ex * (nm) | Em* (nm) |
| AHW1215 | ApoFlamma® H 648 | 648 | 663 |
| AHW1501 | ApoFlamma® H 675 | 675 | 691 |
| AHW1301 | ApoFlamma® H 749 | 749 | 774 |
| AHW1601 | ApoFlamma® H 774 | 774 | 806 |
| AHO1601 | ApoFlamma® H ICG | 785 | 812 |
Overview
ApoFlamma® H series made up of a covalent-connection of CQRPPR hexapeptide (ApoPep) with corresponding fluorophore. ApoPep strongly binds to apoptotic and necrotic cells but weakly binds to live cells. The receptor for ApoPep was histone H1 that exposed on the surface of apoptotic cells. In necrotic cells, ApoPep entered the cells and bound to histone H1. The monitoring of tumor apoptosis in response to chemotherapy can be easily realized with optical imaging technique utilizing ApoFlamma® H series. We recommend ApoFlamma® H series as versatile fluorescent probes for in vitro and in vivo imaging of apoptosis with targeting for histone H1.
Citation & Reference
1. Jung, Kyung Oh. Relationship between Apoptosis Imaging and Radioiodine Therapy in Tumor Cells with Different Sodium Iodide Symporter Gene Expression. Molecular imaging (2014): 1-9.
2. Jung, Hyun-Kyung. In Vivo Near-Infrared Fluorescence Imaging of Apoptosis Using Histone H1-Targeting Peptide Probe after Anti-Cancer Treatment with Cisplatin and Cetuximab for Early Decision on Tumor Response. PloS one 9.6 (2014): e100341.
3. Kim, Soyoun. Advantages of the Phosphatidylserine-Recognizing Peptide PSP1 for Molecular Imaging of Tumor Apoptosis Compared with Annexin V. PloS one 10.3 (2015): e0121171.
4. Muthiah, Muthunarayanan. Intracellular delivery and activation of the genetically encoded photosensitizer Killer Red by quantum dots encapsulated in polymeric micelles. Colloids and Surfaces B: Biointerfaces 116 (2014): 284-294.
5. Muthiah, Muthunarayanan. Formulation of glutathione responsive anti-proliferative nanoparticles from thiolated Akt1 siRNA and disulfide-crosslinked PEI for efficient anti-cancer gene therapy. Colloids and Surfaces B: Biointerfaces 126 (2015): 322-327.
6. Muthiah, Muthunarayanan. MicroRNA delivery with osmotic polysorbitol-based transporter suppresses breast cancer cell proliferation. International journal of biological macromolecules 72 (2015): 1237-1243.
