No More Sales-Anti-Dnmt1 (1037-1386) antibody, affinity-purified (rabbit polyclonal), ChIP grade

No More Sales- inactivated

For assistance or inquiries, please contact us.



Anti-Dnmt1 (1037-1386) antibody, affinity-purified (rabbit polyclonal), ChIP grade


inactived-FNK-70-203

Researchers can use these antibodies and antigens for studying epigenetic regulation of gene expression, X chromosome inactivation, genomic imprinting, and development. Abberant methylation patterns are associated with certain human tumors and developmental abnormalities.

Diseases associated with DNMT1 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant and Neuropathy, Hereditary Sensory, Type I. 

These antibodies have excellent quality and this highly pure antibody can be adapted for Western Blots, ELISA, Immunohistochemistry, Immunofluorescence research with optimization.  

General information 

Description 

Dnmt1 (DNA (cytosine-5-)-methyltransferase 1) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Hypermethylation in promoter regions is asssociated with repression of gene expression. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities (1, 2). This antibody was raised by Prof. S. Tajima of Osaka Univ. (3, 4). 

Figure Immunodetection of Dnmt1
1. Murine erythrolekemia cells, MEL11A2
2. Mouse myoblast cells,C2C12
3. C2C12 carrying Dnmt1 overexpressing plasmid
4. C2C12 carrying negative control plasmid

1~4; Western blotting. 5~8; Immunoprecipitation of SDS denatured Dnmt1. 

References
This product was used in Ref. 3 and 4

1. Di Croce L et al “Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor” Science 295: 1079-82 (2002) PMID: 11834837
2. Rhee I et al ” DNMT1 and DNMT3b cooperate to silence genes in human cancer cells” Nature 416: 552-6 (2002) PMID: 11932749
3. Takagi H et al “Overexpression of DNA methyltransferase in myoblast cells accelerates myotube formation” Eur J Biochem 231: 282-91 (1995) PMID: 7635139
4. Inano K et al “Maintenance-type DNA methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment” J Biochem 128: 315-21 (2000) PMID: 10920268

Aliases for DNMT1 Gene

• DNA Methyltransferase 1 ^2 3 5
• CXXC9 ^2 3 4
• MCMT ^2 3 4
• DNA (Cytosine-5-)-Methyltransferase 1 ^2 3
• DNA (Cytosine-5)-Methyltransferase 1 ^3 4
• CXXC-Type Zinc Finger Protein 9 ^3 4
• DNA Methyltransferase HsaI ^3 4
• DNA MTase HsaI ^3 4
• EC 2.1.1.37 ^4 51
• M.HsaI ^3 4
• DNMT ^3 4
• AIM ^3 4
• ADCADN ³
• HSN1E ³
• DNMT1 ⁵
• Dnmt1 ⁴