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Imaging Probe Types

Product#: DC-Imaging-Probe-Types

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In Vivo Imaging Probes (Fluorescence)


NpFlamma^® HGC series NpFlamma® HGC series is a fluorescent dye incorporated biocompatible and biodegradable chitosan based amphiphilic nanoparticle that enables to selectively detect tumor cells. Chitosan nanoparticles can selectively accumulate in cancer tissues due to high permeability for loose new blood vessels around cancer tissues and retention effect. The polymeric nanoparticles form self-aggregates size of several hundred nanometers in the aqueous system accumulate only in vicinity of cancer tissues. Chitosan particles display low toxicity along with absence of noticeable side effect in vivo, yet they exhibit a long half-life, high stability and aqueous solubility. Thus, NpFlamma® HGC series is an ideal fluorescence agent for in vivo imaging of angiography and tumor progression. In conjunction with NIR dyes, the series allows to observe non-invasive images of cancer metastases and to contrast blood vessel. The hydrophobic nature of NpFlamma® HGC series can embed hydrophobic materials, thus they can be utilized as a selective carrier for hydrophobic cancer drugs such as doxorubicin and paclitaxel, etc. In addition, carboxylic acids on the surface of NpFlamma® HGC series can bind to a variety of biomolecules via amide or ester linkages enabling to utilize them in multi-purposes. NpFlamma^® MMP series Matrix metalloproteinases (MMPs) are a group of calcium-dependent, zinc-containing endopeptidases that that in concert are responsible for the degradation of most extracellular matrix (ECM) proteins during organogenesis, growth and normal tissue turnover. Humans have 23 MMPs family, and the expression and activity of MMPs in adult tissues is normally quite low, but increases significantly in various pathological conditions that may lead into unwanted tissue destruction, tumor growth and metastasis, inflammatory diseases, etc. Cancer cells secrete VEGF and FGF in order to induce angiogenesis in vascular endothelial cells, but cannot reach to vascular endothelial cells as being caught in ECM. Although MMPs are connected with cancer cells survival and expansion, only very small amount of MMPs are synthetized by cancer cell. However, the cancer cells induce inflammatory cells to secrete MMPs for assisting the delivery of VEGF secreted by cancer cells and make peripheral space for angiogenesis. The connection between MMPs and apoptosis, cell migration and angiogenesis enables to utilizing MMPs as tumor markers. An increased expression and activity of MMPs in both tissues and blood of patients with various types of cancer is observed. Annexin V Flamma^® series Annexin V Flamma® series is a rapid and selective probe for labeling of externalized PS, an indicator of intermediate stages of apoptosis. Flamma® dyes display strong absorption, high fluorescence quantum yield and high photostability, and they maintain good fluorescence activity and stability after conjugation to biomolecules, allowing the detection of low-abundance biological structures with great sensitivity. Annexin V Flamma® conjugates can be utilized in fluorescent imaging as well as for flow cytometry of apoptotic cells, and they might be used in combination with other dyes such as propidium iodide (PI) in order to accurately analyze mixed populations of apoptotic and other cells. Annexin V Flamma® probes available as stand-alone reagent or easy-to-us kits. ApoFlamma^® series ApoFlamma® H series made up of a covalent-connection of CQRPPR hexapeptide (ApoPep) with corresponding fluorophore. ApoPep strongly binds to apoptotic and necrotic cells but weakly binds to live cells. The receptor for ApoPep was histone H1 that exposed on the surface of apoptotic cells. In necrotic cells, ApoPep entered the cells and bound to histone H1. The monitoring of tumor apoptosis in response to chemotherapy can be easily realized with optical imaging technique utilizing ApoFlamma® H series. We recommend ApoFlamma® H series as versatile fluorescent probes for in vitro and in vivo imaging of apoptosis with targeting for histone H1. AngioFlamma^® series Integrins are heterodimeric transmembrane receptors for cell adhesion to extracellular matrix (ECM) proteins and play important roles in certain cell-cell adhesions. In addition, they make transmembrane connections to the cytoskeleton and activate many intracellular signaling pathways. Because of their role in tumor angiogenesis and progression, integrins have become important diagnostic and therapeutic targets. To date 24 distinct integrins are known, and among them, integrin αvβ3 is known to strongly involve in the regulation of angiogenesis. The αvβ3 is generally expressed in low levels on the epithelial cells and mature endothelial cells, but it is highly expressed in many solid tumors. The αvβ3 levels correlate well with the potential for tumor metastasis and aggressiveness, which make it an important biological target for development of antiangiogenic drugs and molecular imaging probes for early tumor diagnosis.

NpFlamma® HGC Series

648

675

749

774

HGC IGC

Quick link (Cat.#)	Series	*Ex (nm)**	*Em (nm)**	Common filter set	Excitation source
PNC1201	NpFlamma® HGC 648	648	675	Cy 5	594, 633 nm
PNC1401	NpFlamma® HGC 675	675	698	Cy 5.5	633, 680 nm
PNC1301	NpFlamma® HGC 749	750	782	Cy 7	680 nm
PNC1601	NpFlamma® HGC 774	777	802	Cy 7.5	785 nm
PNC1501	NpFlamma® HGC ICG	785	821	Cy 7.5	785 nm

NpFlamma® MMP Series

MMP-2,9 648

MMP-2,9 675

MMP-2,9 749

MMP-2,9 774

MMP-2,9 ICG

MMP-3,7 648

MMP-3,7 675

MMP-3,7 749

MMP-3,7 774

MMP-3,7 ICG

MMP-13 648

MMP-13 675

MMP-13 749

MMP-13 774

MMP-13 ICG

Quick link (Cat.#)	Series	*Ex (nm)**	*Em (nm)**	Common filter set	Excitation source
PNM0103	NpFlamma® MMP-2,9 648	648	670	Cy 5	594, 633 nm
PNM0104	NpFlamma® MMP-2,9 675	683	694	Cy 5.5	633, 680 nm
PNM0105	NpFlamma® MMP-2,9 749	760	778	Cy 7	785 nm
PNM0106	NpFlamma® MMP-2,9 774	793	810	Cy 7.5	785 nm
PNM0101	NpFlamma® MMP-2,9 ICG	798	835	Cy 7.5	785 nm
PNM0203	NpFlamma® MMP-3,7 648	648	670	Cy 5	594, 633 nm
PNM0204	NpFlamma® MMP-3,7 675	683	694	Cy 5.5	633, 680 nm
PNM0205	NpFlamma® MMP-3,7 749	760	778	Cy 7	785 nm
PNM0206	NpFlamma® MMP-3,7 774	793	810	Cy 7.5	785 nm
PNM0201	NpFlamma® MMP-3,7 ICG	798	835	Cy 7.5	785 nm
PNM0303	NpFlamma® MMP-13 648	648	670	Cy 5	594, 633 nm
PNM0304	NpFlamma® MMP-13 675	683	694	Cy 5.5	633, 680 nm
PNM0305	NpFlamma® MMP-13 749	760	778	Cy 7	785 nm
PNM0306	NpFlamma® MMP-13 774	793	810	Cy 7.5	785 nm
PNM0301	NpFlamma® MMP-13 ICG	798	835	Cy 7.5	785 nm

Annexin V Flamma® Series



648	675	749	774	V-ICG

Quick link (Cat.#)	Series	λEx (nm)	λEm (nm)
XAP1102	Annexin V-FITC Apoptosis detection kit	492	519
XAP1201	Annexin V-Flamma® 488 Apoptosis detection kit	549	564
XAP1301	Annexin V-Flamma® 552 Apoptosis detection kit	648	672
XAP1801	Annexin V-TAMRA Apoptosis detection kit	648	672
XAP2102	Annexin V-FITC	492	519
XAP2202	Annexin V-Flamma® 488	495	519
XAP2302	Annexin V-Flamma® 552	550	565
XAP2802	Annexin V-TAMRA	543	575
XAP2402	Annexin V-Flamma® 648	648	663
XAP2022	Annexin V-Flamma® 675	675	691
XAP2032	Annexin V-Flamma® 749	749	774
XAP2042	Annexin V-Flamma® 774	774	806
XAP2052	Annexin V-ICG	785	821

AngioFlamma® Series

648	675	749	774	ICG

Quick link (Cat.#)	Series	λEx (nm)	λEm (nm)	Common filter set	Excitation source	Size
ARW1025	AngioFlamma® FAM	492	519	FITC	488 nm	0.5mg, 1mg, 5mg
ARW1011	AngioFlamma® 552	550	565	TRITC	488, 532 nm	0.5mg, 1mg, 5mg
ARR1001	AngioFlamma® TAMRA	543	575	TRITC	488, 532 nm	0.5mg, 1mg, 5mg
ARW1415	AngioFlamma® 581	581	596	TRITC	488, 532 nm	0.5mg, 1mg, 5mg
ARW1215	AngioFlamma® 648	648	663	Cy®5	594, 633 nm	0.5mg, 1mg, 5mg
ARW1501	AngioFlamma® 675	675	691	Cy®5.5	633, 680 nm	0.5mg, 1mg, 5mg
ARW1301	AngioFlamma® 749	749	774	Cy®7	680 nm	0.5mg, 1mg, 5mg
ARW1601	AngioFlamma® 774	774	806	Cy®7.5	785 nm	0.5mg, 1mg, 5mg
ARO1601	AngioFlamma® ICG	785	821	Cy®7.5	785 nm	0.5mg, 1mg, 5mg

ApoFlamma® Series

648	675	749	774	ICG

Quick link (Cat.#)	Series	*Ex (nm)**	*Em (nm)**
AHW1215	ApoFlamma® H 648	648	663
AHW1501	ApoFlamma® H 675	675	691
AHW1301	ApoFlamma® H 749	749	774
AHW1601	ApoFlamma® H 774	774	806
AHO1601	ApoFlamma® H ICG	785	812