Aurodox, 5 mg

 

Aurodox produced essentially complete inhibition of poly(Phe) synthesis with a 50% inhibitory concentration at 0.13uM. Type III inhibitor. Aurodox was isolated from secondary metabolites of Streptomyces goldiniensis¹⁾ considered as possibly effective against streptococcus pyogenes infections. It may promote growth in poultry. Contact of aurodix-producing Streptomyces goldiniensis with its antibiotic is necessary for expression of resistance to aurodox. Aurodox inhibits both protein synthesis and the release of elongation factor Tu from the ribosomes in the producing organism. Mutants resistant to growth inhibition by aurodox are also resistant to feedback inhibition of aurodox biosynthesis by antibiotic²⁾.

Origin: Streptomyces sp.

CAS Registry Number: 12704-90-4

CA Index Name: 1-Methylmocimycin

Appearance: Yellow solid

Molecular Formula/ Weight: C₄₄H₆₂N₂O₁₂=810.99

Melting Point: 135-138°C

Purity: >95.0% by HPLC

Solubility: Sol. 1mg/ml ethanol, methanol, DMSO

Handling and Storage: Store at -20°C. Protect from light..