Anti-TRK fused gene Rabbit Polyclonal Antibody
Anti-TRK fused gene Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB113643 |
| Size | ：100 uL |
| Protein full name | ：Protein TFG |
| Synonym | ：FLJ36137, TF6, TFG, TRK fused gene, TRK-fused gene protein, TRKT3 |
| Immunogen | ：Recombinant protein corresponding to Human TRK fused gene |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：43 kDa |
| Observed MW. | ：55 kDa |
| Uniprot ID | ：Q92734 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1: 500-1: 1000 |
293T, HepG2 |
Description
Protein TFG (TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma (TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa (TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
 |
Western blot analysis of TFG (GB113643) at dilution of 1: 1000 |
Aliases for TFG Gene
