/Content/Upload/Product/GB112401-7_1200.png

Anti-Monoamine Oxidase A Rabbit Polyclonal Antibody

Product#: SB-GB112401

$560.00

Qty:

Availability:

Ships in 1-2 Weeks

Description
Reviews (0)

Anti-Monoamine Oxidase A Rabbit Polyclonal Antibody

General information

Cat. No.	：SB-GB112401
Size	：100 uL
Protein full name	：Amine oxidase [flavin-containing] A
Synonym	：Monoamine oxidase type A, MAO-A, Maoa, AOFA
Immunogen	：Recombinant protein corresponding to Mouse Monoamine Oxidase A/MAO-A
Isotype	：IgG
Purity	：Affinity purification
Subcellular location	：Mitochondrion
Uniprot ID	：P21397, Q64133, P21396
Long Term Storage	：-20 ℃ or below
Shipping Condition	：Dry Ice
Storage Buffer	：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.

Application

Applications	Species	Dilution	Positive Tissue
IHC	Human, Mouse, Rat	1: 2000-1: 4000	placenta, kidney, duodenum, colon, heart

Description

Monoamine oxidase A (MAO-A) catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAO-A preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are a cause of Brunner syndrome which is a form of X-linked nondysmorphic mild mental retardation.

	Immunohistochemistry analysis of paraffin-embedded human placenta using MAO-A (GB112401) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded mouse placenta using MAO-A (GB112401) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded rat placenta using MAO-A (GB112401) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded mouse kidney using MAO-A (GB112401) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded mouse duodenum using MAO-A (GB112401) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded rat colon using MAO-A (GB112401) at dilution of 1: 4000

Antigen Characterization

Type: Primary
Application: Western Blot (WB): Used for detecting specific proteins in a sample,ELISA: A plate-based assay technique designed for detecting and quantifying proteins, hormones, antibodies, and antigens.
Species: Human
Recombinant: Yes

Human Diseases

Brunner Syndrome: A rare genetic condition linked to mutations in the MAOA gene, characterized by abnormal behavior and cognitive issues.
Antisocial Personality Disorder: Associated with altered levels of neurotransmitters due to MAOA activity, influencing behavior and emotional regulation.
Prostate Cancer: High MAOA expression correlates with poor prognosis.

Cellular Signaling Pathways

Neurotransmitter Clearance: MAOA plays a crucial role in the metabolism of neurotransmitters like serotonin and dopamine, impacting mood and cognition.
Oxidative Stress Response: Involved in the production of reactive oxygen species (ROS), which can lead to cellular damage and influence cancer progression.
Immune Cell Regulation: Affects tumor-associated immune cell functions, influencing cancer immunotherapy outcomes.

Aliases for MAO-A Gene

GeneCards Symbol: MAOA ²
Monoamine Oxidase A ²³⁵
Amine Oxidase [Flavin-Containing] A ³⁴
Monoamine Oxidase Type A ³⁴
EC 1.4.3.4 ⁴⁴⁹
MAO-A ³⁴
EC 1.4.3 ⁴⁹
BRNRS ³

References

Ma, Yifan, et al. “Targeting Monoamine Oxidase a: A Strategy for Inhibiting Tumor Growth with Both Immune Checkpoint Inhibitors and Immune Modulators - Cancer Immunology, Immunotherapy.” SpringerLink, Springer Berlin Heidelberg, 13 Feb. 2024, link.springer.com/article/10.1007/s00262-023-03622-0.
Cell Signaling Technology. “Maoa Antibody.” Cell Signaling Technology, www.cellsignal.com/products/primary-antibodies/maoa-antibody/66935.
Account - Genecards Suite, www.genecards.org/cgi-bin/carddisp.pl?gene=MAOA.
Maoa Monoamine Oxidase a [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=4128.
Maoa Monoamine Oxidase a [Mus Musculus (House Mouse)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=17161.