Anti-KDM1/LSD1 Rabbit Polyclonal Antibody
Anti-KDM1/LSD1 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112427 |
| Size | ：100 uL |
| Protein full name | ：Lysine-specific histone demethylase 1A |
| Synonym | ：BRAF35-HDAC complex protein BHC110, Kdm1a, Aof2, Kiaa0601, Lsd1, Flavin-containing amine oxidase domain-containing protein 2 |
| Immunogen | ：Recombinant protein corresponding to Mouse KDM1/LSD1 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Nucleus |
| Predicted MW. | ：93 kDa |
| Observed MW. | ：110 kDa |
| Uniprot ID | ：O60341, Q6ZQ88 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 500-1: 1000 |
testis, placenta |
| IHC | Human, Mouse | 1: 1500-1: 3000 | lung cancer, placenta, lung, testis, heart |
| IF | Human, Mouse | 1: 1000-1: 2000 | breast cancer, testis, placenta |
Description
Gene activation and repression is specifically regulated by histone methylation status at distinct lysine residues. Lysine specific demethylase 1 (KDM1/LSD1) is a long-sought histone demethylase that specifically demethylates mono and di methyl histone H3 at K4 and K9. Thus KDM1 is a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor.
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Western blot analysis of LSD1 (GB112427) at dilution of 1: 3000 Lane 1: MCF7 cell lysate Lane 2: A549 cell lysate Lane 3: HT29 cell lysate Lane 4: Mouse testis tissue lysate Lane 5: Mouse placenta tissue lysate Lane 6: Rat placenta tissue lysate |
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using LSD1 (GB112427) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded human placenta using LSD1 (GB112427) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse placenta using LSD1 (GB112427) at dilution of 1: 3000 |
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mmunohistochemistry analysis of paraffin-embedded mouse lung using LSD1 (GB112427) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse testis using LSD1 (GB112427) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using LSD1 (GB112427) at dilution of 1: 3000 |
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Immunofluorescent analysis of paraformaldehyde-fixed human breast cancer using LSD1 (GB112427) at dilution of 1: 2000
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Immunofluorescent analysis of paraformaldehyde-fixed mouse testis using LSD1 (GB112427) at dilution of 1: 2000
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Immunofluorescent analysis of paraformaldehyde-fixed mouse placenta using LSD1 (GB112427) at dilution of 1: 2000
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Aliases for KDM1A Gene
- GeneCards Symbol: KDM1A 2
- Lysine Demethylase 1A 2 3 5
- LSD1 2 3 4 5
- Lysine-Specific Histone Demethylase 1A 2 3 4
- KIAA0601 2 4 5
- BHC110 2 3 5
- AOF2 3 4 5
- KDM1 3 4 5
- [Histone H3]-Dimethyl-L-Lysine(4) FAD-Dependent Demethylase 1A 3 4
- Flavin-Containing Amine Oxidase Domain-Containing Protein 2 3 4
- Amine Oxidase (Flavin Containing) Domain 2 2 3
- BRAF35-HDAC Complex Protein BHC110 3 4
- FAD-Binding Protein BRAF35-HDAC Complex, 110 KDa Subunit 3
- Lysine-Specific Histone Demethylase 1 3
- Lysine (K)-Specific Demethylase 1A 3
- Lysine (K)-Specific Demethylase 1 2
- EC 1.14.99.66 4
- CPRF 3
