Anti-CD3 Zeta Rabbit Polyclonal Antibody
Product#: SB-GB112398
$560.00
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Anti-CD3 Zeta Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112398 |
| Size | ：100 uL |
| Protein full name | ：T-cell surface glycoprotein CD3 zeta chain |
| Synonym | ：T-cell receptor T3 zeta chain, CD247, Cd3z, Tcrz, CD3-eta, TCR zeta chain, TCRzeta, CD3zeta, CD3Q |
| Immunogen | ：Recombinant protein corresponding to Mouse CD3 zeta |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：19 kDa |
| Observed MW. | ：19 kDa |
| Uniprot ID | ：P24161 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse | 1: 400-1: 800 | spleen, lymph node, thymus |
Description
CD247, also known as CD3Z (T-cell surface glycoprotein CD3 zeta chain), belongs to the CD3Z/FCER1G family. CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells. Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
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Western blot analysis of CD3 zeta (GB112398) at dilution of 1: 800 Lane 1: Mouse spleen tissue lysate Lane 2: Mouse lymph node tissue lysate Lane 3: Mouse thymus tissue lysate |
Human Diseases
- Immunodeficiency 25: Associated with defects in T-cell function.
- T-B+ Severe Combined Immunodeficiency: Results from mutations affecting CD3 subunits including CD3 zeta.
Cellular Signaling Pathways
- Plays a critical role in T-cell activation and signal transduction through the T-cell receptor (TCR).
- Phosphorylation of ITAMs (Immunoreceptor Tyrosine Activation Motifs) leads to ZAP70 activation.
- Involved in synapse formation between T cells and antigen-presenting cells.
Aliases for CD247 Gene
- GeneCards Symbol: CD247 2
- CD247 Molecule 2 3 5
- T-Cell Surface Glycoprotein CD3 Zeta Chain 2 3 4
- CD3H 2 3 5
- CD3Q 2 3 5
- CD3Z 3 4 5
- T-Cell Receptor T3 Zeta Chain 3 4
- CD247 Antigen 2 4
- TCRZ 3 4
- T3Z 3 4
- T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3 3
- CD3z Antigen, Zeta Polypeptide (TiT3 Complex) 2
- CD3Z Antigen, Zeta Polypeptide (TiT3 Complex) 3
- CD247 Antigen, Zeta Subunit 3
- TCR Zeta Chain 3
- CD3zeta Chain 3
- CD3-ZETA 3
- IMD25 3
References
- Mer?ep M;Bonifacino JS;Garcia-Morales P;Samelson LE;Klausner RD;Ashwell JD; “T Cell CD3-Zeta Eta Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis.” Science (New York, N.Y.), U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/2845582/.
- T-Cell Surface Glycoprotein Cd3 Zeta Chain.” T-Cell Surface Glycoprotein CD3 Zeta Chain | DrugBank Online, go.drugbank.com/polypeptides/P20963.
- Deswal, Sumit, and Wolfgang W. A. Schamel. “CD3ζ.” SpringerLink, Springer New York, 1 Jan. 1970, link.springer.com/referenceworkentry/10.1007/978-1-4419-0461-4_613.
