Anti-Cortisol Rat monoclonal antibody
Product#: FNK-CRT1G6
$412.85
Availability:
Ships in 1-2 Weeks
Anti-Cortisol Rat Monoclonal Antibody
General information
| Cat. No. | ：FNK-CRT1G6 | ||||||||||||||||||||
| Size | ：1.0 mL | ||||||||||||||||||||
| Host Animal | ：Rat | ||||||||||||||||||||
| Isotype | ：IgG (Rat) | ||||||||||||||||||||
| Purification | ：This antibody was isolated from culture supernatant of hybridoma by Protein G affinity chromatography. | ||||||||||||||||||||
| Purity | ：>80% by SDS-PAGE | ||||||||||||||||||||
| Concentration | ：0.1 mg/mL | ||||||||||||||||||||
| Appearance | ：Clear liquid | ||||||||||||||||||||
| Storage | ：Short term: 4℃; Long term: -20℃ or below. Avoid freeze thaw cycles | ||||||||||||||||||||
| Shipping Condition | ：Dry Ice | ||||||||||||||||||||
| Cross Reactivity |
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| Preservative | ：0.1% Sodium azide | ||||||||||||||||||||
| Presentation | ：Supplied as a liquid in 0.01M Tris, 0.15M NaCl, 0.1% Sodium azide, pH 7.5 | ||||||||||||||||||||
General Characterization
- Type:Prinary
- Application: ELISA ,Western Blot , Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- Species:Human
- Recombinant:No
Human Diseases
- Cushing's syndrome
- Addison's disease
- Depression and anxiety disorders
- Cardiovascular disease
- Type 2 diabetes
- Obesity
- Osteoporosis
- Immune system disorders
- Cognitive impairment and memory loss
- Sleep disorders
- Chronic fatigue syndrome
Cellular signaling pathways
- Hypothalamic-pituitary-adrenal (HPA) axis
- Glucocorticoid receptor (GR) signaling
- Mineralocorticoid receptor (MR) signaling
- cAMP/protein kinase A (PKA) pathway
- MAPK/ERK pathway
- PI3K-Akt signaling pathway
- Notch/Hes signaling (at low concentrations)
- TGFβ-SMAD2/3 signaling (inhibited at high concentrations)
- Hedgehog signaling (inhibited)
- WNT/β-catenin signaling
- Regulation of glucose metabolism and gluconeogenesis
- Modulation of immune response and inflammation
Aliases for Cortisol
- Hydrocortisone
- 11β,17α,21-trihydroxypregn-4-ene-3,20-dione
- Compound F
- 17-Hydroxycorticosterone
References
- Thau, Lauren. “Physiology, Cortisol.” StatPearls [Internet]., U.S. National Library of Medicine, 28 Aug. 2023, www.ncbi.nlm.nih.gov/books/NBK538239/.
- Kusov, Pavel A, et al. “Cortisol Monitoring Devices toward Implementation for Clinically Relevant Biosensing in Vivo.” Molecules (Basel, Switzerland), U.S. National Library of Medicine, 3 Mar. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10005364/.
- Professional, Cleveland Clinic medical. “Cortisol: What It Is, Function, Symptoms & Levels.” Cleveland Clinic, 1 May 2024, my.clevelandclinic.org/health/articles/22187-cortisol.
