Anti Human MR mouse monoclonal antibody (H3122)

Product#: PP-H3122-00
$577.00
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Anti Human MR mouse monoclonal antibody (H3122)
MR: Mineralocorticoid Receptor
 

DiagnoCine offers excellent  Anti-MR | NR3C2 | Mineralocorticoid Receptor Antibody  used for studying Prenatal Exposure, Aldosterone, Diffusion, Cardiovascular Disorders, Tumors Biopsy, Tensor Imaging, Diffusion, Myocarditis, Electrophysiology Research.    

Human diseases include Cardiovascular Disease, Multiple Cancer types, Asthma, Infections, Stroke, Thyroid Tumor, Chronic Liver disease, Myocarditis, Heart Failure Studies, and Fungal lung disease.                                                  
                                                        
Anti-MR | NR3C2 | Mineralocorticoid Receptor Antibody has excellent quality and this highly pure antibody can be adapted for Western blotting, ELISA, Immunoprecipitation, and Immunohistochemistry research with optimization.


General information 

Cat. No. :PP-H3122-00
Size 100 ul
Antigen Species Human    
Host Species Mouse
Cross Reactivity :Human/ Rat 
Purification Ammonium sulfate fractionation.
Clone No :H3122
Lot. A-2
Concentration 1 mg/mL
Ig Class G2a
Nomenclature NR3C2
Application   ELISA : 0.2 ug/mL 
Western Blot : 1 ug/mL
Immunohistochemistry : 20-40 ug/mL
Specificity
This antibody specifically recognizes human MR and cross reacts with mouse and rat MR.
Storage Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots.
    Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended.
Form Physiological saline with 0.1% NaN3 as a preservative
Genbank M16801


Description


Mineralcorticoid receptor (MR; NR3C2) is a member of steroid receptor (AR, ER, GR, PR). Aldosterone binds to MR with a high affinity. MR is expressed in kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and GR can cooperatively form heterodimers.

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Origin

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human MR (2-99 aa).

Note
Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.
 

References

  1. Jae Mi Suh, et al. Mol Endocrinol, Dec. 2006, 20(12): 3412-3420
  2. Jun Qin, et al. Developmemtal Dynamics, 2007, 236: 810-820



Aliases for NR3C2 Gene

  • Nuclear Receptor Subfamily 3 Group C Member 2 2 3 4 5
  • MR 2 3 4
  • Mineralocorticoid Receptor 3 4
  • MCR 3 4
  • MLR 3 4
  • Nuclear Receptor Subfamily 3, Group C, Member 2 Variant 3 3
  • Nuclear Receptor Subfamily 3, Group C, Member 2 2
  • Mineralocorticoid Receptor Delta 3
  • Mineralocorticoid Receptor 1 3
  • Mineralocorticoid Receptor 2 3
  • Aldosterone Receptor 3
  • NR3C2VIT 3
  • NR3C2 5

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