Anti Human LDL receptor Antibody Monoclonal, LR-LL12D10

Product#: BML029
$577.00
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Anti Human LDL receptor Antibody Monoclonal, LR-LL12D10


General information 

Cat. No. :BML029
Size 50µg
Clone :LR-LL12D10
Antigen Human 
Host Animal  Mouse 
Cross Reactivity Human 
Labeled  :Unlabeled
Preparation Produced in mice immunized with synthetic peptides, aa158-175 (WPARCGARPSPQPGRGPC), which is
    corresponding to the ligand binding domain linker site of human low-density lipoprotein (LDL) receptor
    (LDL-R). LDL-R specific IgG was purified from mouse ascites fluid with a proteinA-Sepharose.
Formulation 0.2 µm filtered PBSsolution
Specificity This antibody has been selected for its ability to bind for human LDL-R expressed in CHO cells (ldl-A7).
    No cross-reactivity with human VLDL receptor and apoER2 receptor was confirmed (see ref. 1) 
Application

Western Blot - This antibody can be used at 1.0 µg/mL for western blot analysis (1).
Flow cytometry - This antibody can be used as a 1st antibody for immunohistochemistry.
                                  Please see the references (2) and (3) for details.
Immunohistochemistry - This antibody can be used for immunohistochemistry (4).

Optimal dilutions should be determined by each laboratory for each application.

Immunogen synthetic peptide
Ig Type IgG2a
Storage IgG in PBS solution are stable for twelve months from the date of receipt when stored at-80˚C.
    Avoid repeated freeze-thaw cycles.

 

References

  1. Kosaka et al., Evidence of macrophage form cell formation by very low-density lipoprotein receptor: Interferon-γ inhibition of very  low-density lipoprotein receptor expression and form cell formation in macrophages. Circulation,2001;103:1142-1147.
  2. Takahashi et al., A novel mutation in exon 2 of the low-density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia.ClinGenet,2001;59:290-292. 
  3. Iwasaki et al., The important role for ßVLDLs binding at the forth cysteine of first ligand-binding domain in the low-density lipoprotein receptor. J Hum Genet,2004;49:622-628.
  4.  Motoi et al., Apolipoprotein E receptor 2 is involved in neuritic plaque formation inAPPsw mice.Neurosci Lett,2004;368:144-147


Aliases for LDLR Gene

  • Low Density Lipoprotein Receptor 2 3 5
  • Low-Density Lipoprotein Receptor 3 4
  • LDL Receptor 3 4
  • LDLCQ2 2 3
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 3
  • Familial Hypercholesterolemia 2
  • FHCL1 3
  • LDLR 5
  • FHC 3
  • FH 3
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