Anti Human LDL receptor Antibody Monoclonal, LR-LL12D10
Product#: FNK-BML029
$495.39
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Anti Human LDL receptor Antibody Monoclonal, LR-LL12D10
General information
| Cat. No. | ：FNK-BML029 |
| Size | ：50µg |
| Clone | ：LR-LL12D10 |
| Antigen | ：Human |
| Host Animal | ：Mouse |
| Cross Reactivity | ：Human |
| Labeled | ：Unlabeled |
| Preparation | ：Produced in mice immunized with synthetic peptides, aa158-175 (WPARCGARPSPQPGRGPC), which is corresponding to the ligand binding domain linker site of human low-density lipoprotein (LDL) receptor (LDL-R). LDL-R specific IgG was purified from mouse ascites fluid with a proteinA-Sepharose. |
| Formulation | ：0.2 µm filtered PBSsolution |
| Specificity | ：This antibody has been selected for its ability to bind for human LDL-R expressed in CHO cells (ldl-A7). No cross-reactivity with human VLDL receptor and apoER2 receptor was confirmed (see ref. 1) |
| Application |
：Western Blot - This antibody can be used at 1.0 µg/mL for western blot analysis (1). Optimal dilutions should be determined by each laboratory for each application. |
| Immunogen | ：synthetic peptide |
| Ig Type | ：IgG2a |
| Storage | ：IgG in PBS solution are stable for twelve months from the date of receipt when stored at-80˚C. Avoid repeated freeze-thaw cycles. |
References
- Kosaka et al., Evidence of macrophage form cell formation by very low-density lipoprotein receptor: Interferon-γ inhibition of very low-density lipoprotein receptor expression and form cell formation in macrophages. Circulation,2001;103:1142-1147.
- Takahashi et al., A novel mutation in exon 2 of the low-density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia.ClinGenet,2001;59:290-292.
- Iwasaki et al., The important role for ßVLDLs binding at the forth cysteine of first ligand-binding domain in the low-density lipoprotein receptor. J Hum Genet,2004;49:622-628.
- Motoi et al., Apolipoprotein E receptor 2 is involved in neuritic plaque formation inAPPsw mice.Neurosci Lett,2004;368:144-147
Aliases for LDLR Gene
