4-Trehalosamine, Trehalase Resistant, Preventive Effect on Starch Retrogradation

Cat. No. FNK-15612


Specifications:

CAS# : 51855-99-3
Molecular Formula : C₁₂H₂₃NO₁₀
Molecular Weight : 341.313
Source : Streptomyces sp.
Supplied as : Powder
Purity : >90 % (qNMR)
Long Term Storage : at -20 °C
Solubility : Soluble in MeOH, DMSO and H₂O

Application Notes
4-Trehalosamine (4-amino-4-deoxy-α , α-trehalose) was isolated from fermentation broth of Streptomyces sp. MD303-SF1.1) It showed weak antibacterial activity against some bacterial species, such as E.coli K-12, K.pneumoniae and B.subtilis PCI219, by the cup assay. It was biologically stable against mammalian trehalase digestion and was not hydrolyzed by a purified porcine trehalase. 4-Trehalosamine had preferable characteristics on biological stability against various microbes which degrade trehalose. 4-Trehalosamine is a useful trehalose substitute for various purposes, such as prevention of starch retrogradation, protein stabilization, and protection of microbes during freeze-drying, and high buffer capacity around the neutral pH.

References
1) 4-Amino-4-deoxy-α,α-trehalose, a new metabolite of a Streptomyces. Naganawa H, et al. J Antibiot. 1974 27(2) 145-146.
2) Rediscovery of 4-trehalosamine as biologically stable, mass-producible, and chemically modifiable trehalose analog. Wada S, et al. Adv Biol. 2022 62101309.