Soyasaponin V (Soyasaponin Ba)

Soyasaponin V (Soyasaponin Ba)
 

• CAT Number :FNK-2400224
• CAS Number : 114590-20-4
• Molecular Weight : 959.13
• Molecular Formula : C₄₈H₇₈O₁₉
• Pack size: 10 mg
• Store: Store at 2-10℃ in a dry and dark place.
• Purity: (HPLC) ≥98％

Product Description
Soyasaponin V, also known as Soyasaponin Ba, is a naturally occurring triterpenoid saponin found in soybeans. It is known for its potential health benefits, including anti-inflammatory and anti-cancer properties.

Property

• Chemical Formula: C48H78O19
• Molecular Weight: 953.13 g/mol
• CAS Number: 114590-20-4
• Appearance: White to off-white powder
• Solubility: Soluble in water and methanol

Application and Usage

• Research: Used in pharmacological studies to investigate its bioactive properties, including anti-cancer, anti-inflammatory, and cholesterol-lowering effects.
• Nutraceuticals: Potential ingredient in dietary supplements aimed at promoting cardiovascular health and reducing cancer risk.
• Cosmetics: Incorporated into skincare products for its antioxidant and anti-aging benefits.

Safety and Handling

• Storage: Store in a cool, dry place, away from direct sunlight and moisture.
• Handling: Use personal protective equipment such as gloves and safety glasses. Avoid inhalation, ingestion, and contact with skin and eyes.
• Safety Measures: In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice if necessary.

Involved Human Diseases

Inflammatory disorders: 

• Soyasaponin V demonstrates significant anti-inflammatory properties by inhibiting inflammatory markers and suppressing the NF-κB pathway.

Cancer: 

• Studies suggest potential anti-carcinogenic effects, particularly in suppressing colon cancer cell proliferation.

Metabolic disorders:

•    Obesity: Soyasaponins, including Soyasaponin V, can improve serum lipid profiles and glucose homeostasis in high-fat diet-induced obese mice.
•    Diabetes: Soyasaponin A1 (a related compound) was found to decrease fasting blood glucose and improve insulin resistance.

Cardiovascular diseases: 

• Soyasaponins have shown hypocholesterolemic properties, potentially helping to lower cholesterol levels and prevent dietary hypercholesterolemia.

Liver diseases: 

• Soyasaponins have demonstrated hepatoprotective effects, which may help protect the liver from damage.

Immune system disorders: 

• Soyasaponins have shown immunomodulatory activities, potentially enhancing immune function.

Non-alcoholic fatty liver disease (NAFLD): 

• Soyasaponins were found to decrease liver cholesterol, triglycerides, and steatosis in animal studies.

Cell Signaling Pathways Affected

NF-κB pathway:

• Soyasaponins inhibit the activation of NF-κB by suppressing the phosphorylation of IKKα/β, IκBα, and p65
• They reduce the transactivity of NF-κB and subsequent production of inflammatory mediators like PGE2

PI3K/Akt pathway:

• Soyasaponins suppress LPS-induced activation of PI3K and Akt phosphorylation
• They inhibit Akt activity by up to 50%, associated with reduced phosphorylation of Akt at serine 473

MAPK/ERK pathway:

• Soyasaponins enhance ERK1/2 activity by about 60%
• Increased ERK1/2 activity is necessary for soyasaponin-induced autophagy in colon cancer cells

TLR4/MyD88 signaling:

• Soyasaponins downregulate MyD88 expression and suppress recruitment of TLR4 and MyD88 into lipid rafts
• They reduce phosphorylation of IRAK-4 and IRAK-1, and decrease TRAF6 levels

Raf-1 kinase:

• Soyasaponin treatment increases Raf-1 kinase activity by up to 200%, potentially modulating the enhanced ERK1/2 activity

Antioxidant pathways:

• Soyasaponins reduce LPS-induced production of reactive oxygen species (ROS)
• They elevate SOD activity and the GSH/GSSG ratio, enhancing antioxidant defenses

This comprehensive product description provides essential information on Soyasaponin V (Soyasaponin Ba) for researchers and consumers interested in its applications and benefits.