Pyridomycin, Antimycobacterial, Enoyl-ACP Reductase Inhibitor

                                                             


Cat.No: FNK-10080

Size: 2 mg

Storage: -20 °C 

Molecular Weight: 540.573

Purity: > 90% (HPLC)

CAS#: 18791-21-4

Molecular Formula: C₂₇H₃₂N_4O8 

Source:  Streptomyces sp.

Supplied as: Powder

Solubility: Soluble in MeOH, DMSO

The chemical structure was confirmed by NMR and HRMS. 
 

Appicaltion

Pyridomycin is an antimycobacterial antibiotic produced by Streptomyces pyridomyceticus^.1),2),3) It inhibited the growth of Mycobacterium tuberculosis at 1.6 μg/ml.¹⁾ Pyridomycin inhibited enoyl-ACP reductase, InhA, in a different manner from isoniazid.⁴⁾ It competitively inhibited InhA by bridging NADH- and lipid substrate-binding pockets.⁵⁾ Mutations in catalase-peroxidase, KatG, cause isoniazid resistance in M. tuberculosis. Pyridomycin similarly inhibited both isoniazid-resistant strains harboring KatG mutations and wild-type M. tuberculosis. ⁴⁾
 

References

1) A new antibiotic, pyridomycin. Maeda K, et al. J. Antibiot. 1953 6(3)140.

2) The chemistry of pyridomycin. Ogawara H, et al. Chem. Pharm. Bull. 1968 16(4) 679-687.

3) Structure of pyridomycin. Koyama G, et al. Tetrahedron Lett. 1967 37 3587-3590.

4) Towards a new tuberculosis drug: pyridomycin - nature's isoniazid. Hartkoorn R, et al. EMBO Mol Med. 2012 10 1032-42.

5) Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA. Hartkoorn R, et al. Nat Chem Biol. 2014 10 96-8.