Pronqodine A (Prostaglandin release inhibitor)

                                                                         

Cat.No: FNK-17684

Size: 1 mg

Storage: -20℃

Molecular Weight: 194.208

Purity: > 98% (HPLC)

CAS#: 1424195-39-0

Molecular Formula: C₈H₆N₂O₂S

Source: Chemically synthesized

Appearance: Powder

Solubility: Soluble in H₂O, MeOH, DMSO, Insoluble in Hexane, EtOAc

The chemical structure was confirmed by NMR and HRMS.
 

Application

Pronqodine A was isolated from culture filtrate of Streptomyces sp. MK832-95F2. ¹⁾ Pronqodine A was reduced to unstable hydroquinone by NAD(P)H quinone oxidoreductase 1 (NQO1) and inhibited cyclooxygenase. Thus, pronqodine A inhibited prostaglandin release in selectively activated NQO1 expressing cells. Pronqodine A and aulosirazole were synthesized and they inhibited indoleamine2.3-dioxygenase.²⁾
 

References

1) NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactitivated proquodine A regulates prostaglandin release from human synovial sarcoma cells. Nakae K, et al. J Nat Prod. 2013 76(4) 510-515.

2) Synthesis and intracellular redox cycling of natural quinones and their analogues and identification of indoleamine-2,3 -dioxygenase (IDO) as potential target for anticancer activity. Blunt CE, et al. Angew Chem int Ed. 2015 54(6) 8740-8745.