Ppc-1, MitoUncoupler

Ppc-1, MitoUncoupler

Cat. No. FNK-FDV-0011
Storage Store at -20℃. For reconstituted solution, store at +4℃. Protected from light.
Size 5 mg
Reconstituion Reconstitute at 10 mM as stock solution in DMSO. ※In the case of poor solubility, vortex or heat it at 37℃.

Description

Increasing mitochondria's oxigen consumption without inhibiting ATP synthesis
Ppc-1, MitoUncoupler

According to papers, following effects are reported in Ppc-1:

• Ppc-1 stimulates oxygen consumption without inhibiting ATP synthesis in mitochondria, isolated from mouse liver. 1), 2)
• Ppc-1 administrated mouse shows inhibition of weight gain, without affecting liver and kidney. 1), 2)
• Cell proliferation is inhibited without inducing cell death, in Ppc-1 treated 3T3-L1 cells. 3)

• Comparatively mild uncoupling activity.
• Low effect on ATP synthesis or degradation.
• Low active oxygen generation.
• Low cytotoxicity.
• Cell proliferation is inhibited by adding Ppc-1 to culture medium.
• Chemical Name ：3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
• CAS number ：1245818-17-0
• Molecular Formula ：C21H25NO4
• Molecular Weight ：355.43
• Purity ：>=98%
• Soluble in DMSO

Reference

1. Suzuki T, et. al, PLoS One. 2015 Feb10; 10(2):e0117088.
2. Kikuchi H, et. al, Bioorg Med Chem., 23(1): 66-72(2015).
3. Kikuchi H, et. al, Tetrahedron, 66: 6000-6007(2010).