Ppc-1, MitoUncoupler

Product#: FDV-0011
$200.00
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Ppc-1, MitoUncoupler

Cat. No. FDV-0011
Storage Store at -20℃. For reconstituted solution, store at +4℃. Protected from light.
Size 5 mg
Reconstituion Reconstitute at 10 mM as stock solution in DMSO. ※In the case of poor solubility, vortex or heat it at 37℃.

Description

Increasing mitochondria's oxigen consumption without inhibiting ATP synthesis
Ppc-1, MitoUncoupler
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Ppc-1 is a newly isolated molecule from Polysphondylium pseudo-candidum. It shows comparatively mild uncoupling activity in Mitochodria.

According to papers, following effects are reported in Ppc-1:

  • Ppc-1 stimulates oxygen consumption without inhibiting ATP synthesis in mitochondria, isolated from mouse liver. 1), 2)
  • Ppc-1 administrated mouse shows inhibition of weight gain, without affecting liver and kidney. 1), 2)
  • Cell proliferation is inhibited without inducing cell death, in Ppc-1 treated 3T3-L1 cells. 3)
Product Background
Ppc-1 is a novel small molecule derived from cellular slime mold Polysphondylium pseudo-candidum. It enhances oxygen consumption in a dose-dependent manner and acts as moderate mitochondrial oxidative phosphorylation uncoupler without adverse effects on ATP production. In addition, Ppc-1 shows little cytotoxicity and enable us to use it in vivo.

Features
  • Comparatively mild uncoupling activity.
  • Low effect on ATP synthesis or degradation.
  • Low active oxygen generation.
  • Low cytotoxicity.
  • Cell proliferation is inhibited by adding Ppc-1 to culture medium.
  • Chemical Name :3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
  • CAS number :1245818-17-0
  • Molecular Formula :C21H25NO4
  • Molecular Weight :355.43
  • Purity :>=98%
  • Soluble in DMSO

Reference

  1. Suzuki T, et. al, PLoS One. 2015 Feb10; 10(2):e0117088.
  2. Kikuchi H, et. al, Bioorg Med Chem., 23(1): 66-72(2015).
  3. Kikuchi H, et. al, Tetrahedron, 66: 6000-6007(2010).

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