Neochlorogenic Acid

Neochlorogenic Acid
 

• CAT Number : FNK-2400263
• CAS Number : 906-33-2
• Molecular Weight : 354.3
• Molecular Formula : C₁₆H₁₈O₉
• Pack size: 10 mg
• Store:  Store at -20℃ in a dry and dark place.
• Purity: (HPLC) ≥98％

Product Description
Neochlorogenic acid is a naturally occurring chlorogenic acid isomer found in various plants, particularly in coffee beans and some fruits. It is a phenolic compound with antioxidant properties.

Property

• Chemical Formula: C₁₆H₁₈O₉
• Molecular Weight: 354.31 g/mol
• Appearance: Likely a white to off-white crystalline powder
• Solubility: Soluble in water and polar organic solvents

Application and Usage

• Research: Used in studies investigating its antioxidant and biological activities
• Nutraceuticals: Potential ingredient in dietary supplements due to its health benefits
• Food Industry: May be used as a natural antioxidant in food products
• Analytical Standard: Used as a reference compound in coffee and plant extract analysis

Safety and Handling

• Storage: Store in a cool, dry place, protected from light
• Handling: Use appropriate personal protective equipment
• Safety Measures: For research use only; not for human consumption without proper testing and approval

Involved Human Diseases

• Liver Diseases
  • NCA shows protective effects against liver disorders:
    • - It attenuates hepatic lipid accumulation and improves nonalcoholic fatty liver disease (NAFLD) by downregulating miR-34a and activating the SIRT1/AMPK pathway.
    • - NCA reduces the expression of lipogenesis-associated genes and increases the expression of fatty acid β-oxidation enzymes, helping to maintain lipid homeostasis in the liver.
• Cardiovascular Diseases
• The compound may have beneficial effects on heart health:
  • - NCA's antioxidant properties could potentially protect against cardiovascular diseases by reducing oxidative stress.
  • - It may help improve vascular health by inhibiting the adhesion and chemotaxis of neutrophils to vascular endothelial cells.
• Metabolic Disorders
  • NCA shows promise in addressing metabolic issues:
    •  It has been studied for its effects on glucose metabolism, suggesting potential benefits for diabetes management.
    • - NCA demonstrates hypolipidemic effects, which could be beneficial in treating obesity and related metabolic disorders.
• Neurological Diseases
  • The neuroprotective properties of NCA may be beneficial for brain health:
    • It has shown potential in protecting against neurodegenerative diseases like Alzheimer's and Parkinson's by reducing oxidative stress and neuroinflammation.
    • NCA may cross the blood-brain barrier, exerting direct neuroprotective effects on brain tissue.
• Inflammatory Conditions
  • NCA exhibits anti-inflammatory properties that could be beneficial in various inflammatory disorders:
    • It has been shown to reduce the expression of inflammatory markers and inhibit inflammatory pathways.

Cell Signaling Pathways Affected

• AMPK/Nrf2 Pathway
  • nCGA activates the AMPK/Nrf2 signaling pathway, which plays a crucial role in combating oxidative stress and reducing inflammation. Specifically:
    • nCGA increases the expression of HO-1 by activating the AMPK/Nrf2 pathway
    • This activation leads to increased production of antioxidant enzymes
    • The protective effects of nCGA can be reversed by AMPK inhibitors, highlighting the importance of this pathway
• NF-κB Pathway
  • nCGA inhibits the activation of the NF-κB signaling cascade, which is a key regulator of inflammatory responses:
    • - It suppresses the phosphorylation of IKK, IκB, and p65 proteins
    • - nCGA also inhibits the upstream TLR4/MyD88 signaling that leads to NF-κB activation
    • - This inhibition results in reduced production of pro-inflammatory cytokines like TNF-α and IL-6
• MAPK Pathway
  • The MAPK signaling pathway, which includes ERK, p38, and JNK, is also modulated by nCGA[7]:
    • nCGA inhibits the phosphorylation of ERK1/2, p38, and JNK
    • This inhibition leads to reduced inflammatory responses and oxidative stress
    • In cardiac injury models, nCGA's protective effects are linked to JNK pathway inhibition
• Other Affected Pathways
  • JAK-STAT Pathway: nCGA attenuates JAK-1 and STAT-1 phosphorylation, which are involved in inflammatory signaling
  • PI3K/Akt Pathway: nCGA treatment decreases the levels of PI3K and phosphorylated Akt in certain cell types
  • Ras/ERK Pathway: nCGA nullifies the OH-induced upregulation of Ras and phosphorylated ERK