Monoclonal Antibody Against Human CEA (4230)

Monoclonal Antibody Against Human CEA (4230)

 

• Type: Primary
• Application: ELISA (Enzyme-Linked Immunosorbent Assay), Western Blot, Immunohistochemistry
• Species: Human
• Recombinant: Yes

• Colorectal Cancer: CEA is the most widely used biomarker for colorectal cancer. Elevated levels are associated with disease progression and can be used for monitoring treatment response and detecting recurrence.
• Lung Cancer: CEA is elevated in 40-50% of patients with non-small cell lung cancer and can be used as a prognostic marker.
• Breast Cancer: CEA levels are elevated in 30-50% of breast cancer patients and correlate with disease stage.
• Pancreatic Cancer: CEA is a useful marker for monitoring treatment response and detecting recurrence in pancreatic cancer patients.

• Cell Adhesion and Migration: CEA acts as a cell-cell adhesion molecule, influencing cell-cell interactions and cell migration processes.
• Angiogenesis: CEA may play a role in promoting angiogenesis, the formation of new blood vessels, which is crucial for tumor growth and metastasis.
• Immune Modulation: CEA can modulate immune responses by interacting with immune cells and affecting their activation and function.
• Apoptosis: CEA may be involved in regulating apoptosis, or programmed cell death, which can contribute to tumor progression and metastasis.

• Carcinoembryonic Antigen
• CEA Test
• CEA Assay
• CD66e
• CEACAM5
• Meconium antigen 100

• “Cea (CEA31) Mouse Monoclonal Antibody.” Diagnostics, diagnostics.roche.com/global/en/products/lab/carcinoembryonic-antigen-cea31-rtd000737.html. 
• H, Wu, et al. “A Photo-Cross-Linking GlcNAc Analog Enables Covalent Capture of N-Linked Glycoprotein-Binding Partners on the Cell Surface.” (MA5-14675), www.thermofisher.com/antibody/product/CEA-Antibody-clone-1106-Monoclonal/MA5-14675. 
• “CEA Test: Carcinoembryonic Antigen Levels and Results.” City of Hope, City of Hope, 15 Nov. 2021, www.cancercenter.com/diagnosing-cancer/lab-tests/cea-test. 
• Professional, Cleveland Clinic medical. “CEA Test (Carcinoembryonic Antigen): What It Is & Results.” Cleveland Clinic, 1 May 2024, my.clevelandclinic.org/health/diagnostics/22744-cea-test-carcinoembryonic-antigen. 
• Kankanala, Vijaya L. “Carcinoembryonic Antigen.” StatPearls [Internet]., U.S. National Library of Medicine, 23 Jan. 2023, www.ncbi.nlm.nih.gov/books/NBK578172/. 
• Kira H. Bramswig, Marina Poettler, Matthias Unseld, Friedrich Wrba, Pavel Uhrin, Wolfgang Zimmermann, Christoph C. Zielinski, Gerald W. Prager; Soluble Carcinoembryonic Antigen Activates Endothelial Cells and Tumor Angiogenesis. Cancer Res 15 November 2013; 73 (22): 6584–6596. https://doi.org/10.1158/0008-5472.CAN-13-0123
• Bernhard B. Singer, Inka Scheffrahn, Robert Heymann, Kristmundur Sigmundsson, Robert Kammerer, Bjo?rn O?brink; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Expression and Signaling in Human, Mouse, and Rat Leukocytes: Evidence for Replacement of the Short Cytoplasmic Domain Isoform by Glycosylphosphatidylinositol-Linked Proteins in Human Leukocytes1. J Immunol 15 May 2002; 168 (10): 5139–5146. https://doi.org/10.4049/jimmunol.168.10.5139
• Hensel, J. A., Khattar, V., Ashton, R., & Ponnazhagan, S. (2018). Recombinant AAV-CEA Tumor Vaccine in Combination with an Immune Adjuvant Breaks Tolerance and Provides Protective Immunity. Molecular therapy oncolytics, 12, 41–48. https://doi.org/10.1016/j.omto.2018.12.004