Leuhistin (hydrochloride) (Aminopeptidase M Inhibitor)(Aminopeptidase N inhibitor)

                                                                                                               
        


Cat.No: FNK-18718

Size: 1 mg

Storage:  -20℃

Molecular Weight: 277.749

Purity:>95% (HPLC)

CAS#:129085-76-3 (free form)

Molecular Formula:C₁₁H₁₉N₃O₃ •HCl

Source: Bacillus sp.

Appearance: Powder

Solubility: Soluble in H₂O, MeOH, DMSO

The chemical structure was confirmed by NMR and HRMS.
 

Application

Leuhistin was isolated from culture filtrate of Bacillus laterosporus BMI156-14. ¹⁾ The structure was determined by NMR studies, chemical analysis and X-ray diffraction analysis. ²⁾ Leuhistin inhibited aminopeptidase M (IC₅₀: 0.2 μg/ml). It weaky inhibited aminopeptidases A and B but did not inhibit leucyl aminopeptidase at 100 μg/ml.¹⁾

References

1) Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14. I. taxonomy, production, isolation, physico-chemical properties and biological activities. Aoyagi T, et al. J Antibiot. 1991 44(6) 573-578.
 

2) Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14. II. Yoshida S, et al. J Antibiot. 1991 44(6) 579-581.