Dihydrocurcumin

Dihydrocurcumin
 

• CAT Number : FNK-NH040702
• CAS Number : 76474-56-1, 943330-36-7
• Molecular Weight : 370.40
• Molecular Formula : C₂₁H₂₂O₆
• Pack size: 5 mg
• Store: 2－10 ℃
• Purity: >99%(HPLC)

Product Description

• Dihydrocurcumin is a metabolite of curcumin, exhibiting potential anti-inflammatory and antioxidant properties similar to its parent compound.

Property

• Chemical Name: Dihydrocurcumin
• Molecular Formula: C₂₁H₂₂O₆
• Molecular Weight: 370.40 g/mol
• Appearance: Likely a yellow to orange powder

Application and Usage

• Used in research studies investigating anti-inflammatory and antioxidant effects
• Potential applications in pharmaceutical and nutraceutical development

Safety and Handling

• Handle with appropriate personal protective equipment including gloves and safety goggles
• Store in a cool, dry place, protected from light and moisture
• Avoid inhalation, ingestion, and contact with skin and eyes

Involved Human Diseases

Dihydrocurcumin has been studied for its effects on NAFLD, a condition characterized by excessive fat accumulation in the liver not due to alcohol consumption. Research indicates that dihydrocurcumin can ameliorate lipid accumulation, oxidative stress, and insulin resistance in liver cells.

In vitro studies using oleic acid-induced liver cell models (L02 and HepG2 cells) have demonstrated that dihydrocurcumin can regulate lipid metabolism and improve glucose uptake. It achieves this by modulating key signaling pathways, such as the peroxisome proliferator-activated receptor-α (PPARα) and the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which are crucial for lipid and glucose metabolism.


Involved Cell Signaling Pathway