CAS# : 132971-59-6 Molecular Formula : C11H10O5 Molecular Weight : 222.196 Source : Chemically synthesized Supplied as : Powder Purity : >98 % (HPLC) Long Term Storage : at -20 °C Solubility : Soluble in acetone, acetonitrile and DMSO. Insoluble in H2O
Application Notes
Cytogenin was first isolated from fermentation broth of Streptoverticillium eurocidicum MI43-37F11as an immunomodulative antitumor substance. Total synthesis of cytogen in was also performed. It showed antitumor activity against Ehrlich carcinoma and IMC carcinoma in mice by oral administration. Cytogenin showed weak cytotoxicity against L1210 and other cancer cells at 50-100 μg/ml, and it was not toxic to mice at 200 mg/kg (po). Cytogenin had an anti-inflammatory activity against collagen-induced arthritic model in mice. It had anti-diabetic effect using streptozotocin- induced diabetes in mice. Cytogenin suppressed angiogenes is induced by malignant tumor cells,S-180,in a mouse dorsal air sac assay system.
References
1) Cytogenin, a novel antitumor substance. Kumagai H, et al. J Antibiot. 1990 43(11) 1505-1507.
2) Antitumor activity of cytogenin. Kumagai H, et al. J Antibiot. 1995 48(2) 175-178.
3) Production of antibiotic MI43-37F11 and production intermediate. Yoshioka T, et al. Japan patent JPH04112884A.
4) Action of cytogeninon lymphoid cells and their cytokine production. Kumagai H, et al. J Antibiot. 1995 48(4) 317-320.
5) Effects of cytogenin, a novel anti-arthritic agent,-on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rat. Int J Tiss Reac. 1994 16 155-162.
6) Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice. Kumagai H, et al. J Antibiot. 2005 58(3) 202-205.
7) Effects of cytogenin, a novel microbial product, on embryonic and tumor cell-induced angiogenic responses in vivo. Oikawa T, et al. Anticancer Res. 1997 17(3C) 1881-1886.
