Anti-Rb Rabbit Polyclonal Antibody
Product#: SB-GB112449
$560.00
Availability:
Ships in 1-2 Weeks
Anti-Rb Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112449 |
| Size | ：100 uL |
| Protein full name | ：Retinoblastoma-associated protein |
| Synonym | ：p110-RB1, pRb, Rb, pp105, Rb1, Rb-1, p105-Rb, OSRC, Prepro retinoblastoma associated protein |
| Immunogen | ：Recombinant protein corresponding to Mouse Rb |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：105 kDa |
| Observed MW. | ：105 kDa |
| Uniprot ID | ：P13405 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse | 1: 300-1: 600 |
kidney |
Description
RB1, also named as pp110, pRb and p105 Rb, belongs to the retinoblastoma protein (RB) family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes.Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human RB1.
 |
Western blot analysis of Rb (GB112449) at dilution of 1: 600 Lane 1: Mouse kidney tissue lysate |
Aliases for Rb Gene
- GeneCards Symbol: RB1 2
- RB Transcriptional Corepressor 1 2 3 5
- PPP1R130 2 3 5
- RB 2 3 5
- Protein Phosphatase 1, Regulatory Subunit 130 2 3
- Prepro-Retinoblastoma-Associated Protein 2 3
- Retinoblastoma-Associated Protein 3 4
- Retinoblastoma 1 2 3
- P110-RB1 3 4
- P105-Rb 3 4
- Pp110 3 4
- OSRC 3 5
- PRb 3 4
- Exon 17 Tumor GOS561 Substitution Mutation Causes Premature Stop 3
- GOS563 Exon 17 Substitution Mutation Causes Premature Stop 3
- Retinoblastoma Suspectibility Protein 3
- Osteosarcoma 2
- Rb 4
