Anti-NADPH oxidase 4 Rabbit Polyclonal Antibody
Anti-NADPH oxidase 4 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB11347 |
| Size | ：100 uL |
| Protein full name | ：NADPH oxidase 4 |
| Synonym | ：NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse NOX4 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：70 kDa |
| Observed MW. | ：70 kDa |
| Subcellular location | ：Endoplasmic reticulum membrane, Cell membrane, Cell junction |
| Uniprot ID | ：Q9JHI8, Q9NPH5, Q924V1 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Rat | 1: 1000-1: 2000 |
skeletal muscle, lung, kidney |
| IHC |
Human, Mouse, Rat |
1: 1000-1: 2000 |
kidney |
| IF | Human, Mouse, Rat | 1: 1000-1: 2000 | kidney |
Description
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. Nox4 protects the vasculature against inflammatory stress.Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.
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Western blot analysis of NOX4 (GB11347) at dilution of 1: 1000. Lane 1: Rat skeletal muscle tissue lysate Lane 2: Rat lung tissue lysate Lane 3:Rat kidney tissue lysate |
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Immunohistochemistry analysis of parafffin-embedded human kidney using NOX4 (GB11347) at dilution of 1: 1000
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Immunohistochemistry analysis of parafffin-embedded mouse kidney using NOX4 (GB11347) at dilution of 1: 1000
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Aliases for NOX4 Gene