Anti-Mouse CHTF18 (FLJ00069) Polyclonal Antibody, Rabbit

Product#: FNK-MFL0069AF

$495.39

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Anti-Mouse CHTF18 (FLJ00069) Polyclonal Antibody, Rabbit

General information

Cat. No.	：FNK-MFL0069AF
Quantity	：50 µg (250 µL)
Gene	：mouse CTF18, chromosome transmission fidelity factor 18 homolog (mCHTF18, mFLJ00069)
Immunogen	：GX0930 (GST-fusion protein, 191 amino acids) EKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREI EMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPVPRNHEQRLEHIMTRATVQ EQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYI RDLL
Format	：Affinity Purified Rabbit IgG
Constitution	：PBS containing with 50% glycerol and 0.02% of NaN₃
Antigen Species	：Mouse
Host Species	：Rabbit
Label	：Unlabeled
Cross Reactivity	：Mouse
Application	：Western blotting (1 : 1,000), Other applications have not been tested.
Specificity	：Specific to recombinant protein GX0930. This antibody detects mCHTF18 protein. Other species have not been tested.
Storage	：Store at -20°C. Avoid freeze-thaw cycles.
Shipping Condition	：Dry Ice

Antigen Characterization

Type:Primary
Application:Western Blot (WB): Used for detecting and quantifying specific proteins.,ELISA: Employed for measuring protein concentrations in various samples.
Species:Human
Recombinant:Yes

Human Diseases

Infertility: Disruption of CHTF18 has been linked to reduced sperm concentration and abnormal spermatogenesis, leading to male subfertility.
Cancer: Potential involvement in genomic stability may relate to tumorigenesis when CHTF18 function is impaired.
Genetic Disorders: Mutations or dysregulation of CHTF18 may contribute to developmental issues due to its role in chromosome transmission fidelity.
Neurodegenerative Diseases: Implications in DNA repair mechanisms could affect neuronal health and function.

Cellular Signaling Pathways

DNA Repair Pathway: Functions in the repair of double-strand breaks during meiosis, essential for maintaining genomic integrity.
Chromosome Segregation: Plays a critical role in ensuring accurate chromosome segregation during cell division, particularly during meiosis.
Germ Cell Development: Involved in pathways regulating spermatogenesis and oogenesis, influencing fertility outcomes.
Cell Cycle Regulation: May interact with other factors involved in cell cycle progression and stability.

Aliases for CHTF18 Gene

References

Okazaki,N. et al.: DNA Res., 10(1), 35 (2003).
Berkowitz, Karen M., et al. “Disruption of CHTF18 Causes Defective Meiotic Recombination in Male Mice.” PLOS Genetics, Public Library of Science, journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1002996. Accessed 27 Sept. 2024. '
CHTF18 Chromosome Transmission Fidelity Factor 18 [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene/63922. Accessed 28 Sept. 2024.
CHTF18 Protein Expression Summary - the Human Protein Atlas, www.proteinatlas.org/ENSG00000127586-CHTF18.
Account - Genecards Suite, www.genecards.org/cgi-bin/carddisp.pl?gene=CHTF18.
CHTF18 Recombinant Protein Antigen.” Novus Biologicals, www.novusbio.com/products/chtf18-recombinant-protein-antigen_nbp2-55371pep.