Anti-MUC1/CD227 Rabbit pAb

Cat. No.: SB-GB115321

Protein full name: Mucin-1

Antigen name: MUC1/CD227

Alias: ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM, PEMT, Episialin, EAM, CA 15-3

Resource: Rabbit Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Human CD227

Uniprot ID: P15941

Isotype: IgG

Purity: Affinity Purification

Subcellular location: Cell membrane, cytoplasm

Predicted MW.: 122 kDa

Observed MW.: 180-300 kDa

Volume: 100 µL

Storage: -20ºC

 

Description

Mucin 1 (MUC1 [CD227]) is a type I membrane-tethered glycopro tein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aber rantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans.MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling.
 

Applications

Applications	Species	Dilution	Positive Sample
WB	Human	1:300 - 1:600	DU 145
IHC/IF	Human	1:500 - 1:1000	Endometrial cancer, breast cancer, kidney

 

Images

	Western blot analysis of MUC1 (GB115321) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin embedded human endometrial cancer using CD227 (GB115321) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin embedded human breast cancer using CD227 (GB115321) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin embedded human kidney using CD227 (GB115321) at dilution of 1: 500

 

References

• Chang, M., et al., Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer. Journal of Oncology. 2022; 2022: 1533779
• Chen, Z.-R., et al., Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling. Anesthesia & Analgesia. 2023; 137: 426-439
• Elleithi, Y.A., A.M. El-Gayar, Simvastatin Induces Apoptosis And Suppresses Hepatocellular Carcinoma Induced In Rats. Applied Biochemistry and Biotechnology. 2023; 195: 1656-1674
• He, S., et al., Dapagliflozin Protects Methamphetamine-Induced Cardiomyopathy by Alleviating Mitochondrial Damage and Reducing Cardiac Function Decline in a Mouse Model. Frontiers in Pharmacology. 2022; 13: 925276
• Jia, Y., et al., Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin. Molecular Cancer. 2021; 20: 162
• Lin, S.-p., et al., Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia. Acta Pharmacologica Sinica. 2021; 42: 1069-1079
• Gu, Z., et al., Tilapia head glycolipids protect mice against dextran sulfate sodium-induced colitis by ameliorating the gut barrier and suppressing NF-kappa B signaling pathway. International Immunopharmacology. 2021; 96: 107802
• Wang, J., et al., Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells. Archives of Pharmacal Research. 2021; 44: 1025-1036
• Wang, Y., et al., Deletion of LCMR1 in alveolar type II cells induces lethal impairment of lung structure and function in adult mice. J Thorac Dis. 2023; 15: 1445-1459
• Xu, Y., et al., Therapeutic Effects of Zoledronic Acid-Loaded Hyaluronic Acid/Polyethylene Glycol/Nano-Hydroxyapatite Nanoparticles on Osteosarcoma. Frontiers in Bioengineering and Biotechnology. 2022; 10: 897641
• Taha, M., et al., Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its Neuroinflammation, Synaptic Dysplasticity and Apoptosis. Pharmaceuticals. 2022; 15: 918
• Xiong, Z., et al., Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis. iScience. 2024; 27: 109674

Notes

1. This product is intended for research only.