Anti-ClC-5 Rabbit Polyclonal Antibody
Product#: SB-GB112387
$560.00
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Anti-ClC-5 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112387 |
| Size | ：100 uL |
| Protein full name | ：H(+)/Cl(-) exchange transporter 5 |
| Synonym | ：Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, Clcn5, Clc5, Voltage gated chloride ion channel CLCN5, NPHL1 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse ClC-5 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Golgi apparatus, Endosome, Cell membrane |
| Uniprot ID | ：Q9WVD4, P51796 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Rat | 1: 100-1: 200 | kidney |
Description
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria.
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Immunohistochemistry analysis of paraffin-embedded human kidney using ClC-5 (GB112387) at dilution of 1: 200 |
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Immunohistochemistry analysis of paraffin-embedded rat kidney using ClC-5 (GB112387) at dilution of 1: 200 |
Aliases for CLCN5 Gene
- GeneCards Symbol: CLCN5 2
- Chloride Voltage-Gated Channel 5 2 3 5
- ClC-5 2 3 4 5
- HCIC-K2 2 3 5
- DENTS 2 3 5
- XLRH 2 3 5
- CLC5 2 3 5
- XRN 2 3 5
- Chloride Channel, Voltage-Sensitive 5 2 3
- H(+)/Cl(-) Exchange Transporter 5 3 4
- Chloride Transporter ClC-5 3 4
- HClC-K2 2 5
- CLCK2 3 4
- NPHL1 3 5
- NPHL2 3 5
- Voltage-Gated Chloride Ion Channel CLCN5 3
- Nephrolithiasis 1 (X-Linked) 2
- Nephrolithiasis 2, X-Linked 2
- Chloride Channel Protein 5 4
- Chloride Channel 5 2
- Dent Disease 2
- DENT1 3
References
- Günther, W, et al. “CLC-5, the Chloride Channel Mutated in Dent’s Disease, Colocalizes with the Proton Pump in Endocytotically Active Kidney Cells.” Proceedings of the National Academy of Sciences of the United States of America, U.S. National Library of Medicine, 7 July 1998, www.ncbi.nlm.nih.gov/pmc/articles/PMC20931/.
- Clcn5 Chloride Voltage-Gated Channel 5 [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene/1184.
- Bank, RCSB Protein Data. “2JA3: Cytoplasmic Domain of the Human Chloride Transporter CLC-5 in Complex with ADP.” RCSB PDB, www.rcsb.org/structure/2ja3.
- CLCN5 Gene: Medlineplus Genetics.” MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/genetics/gene/clcn5/.
- P;, Hryciw DH;Ekberg J;Pollock CA;Poronnik. “CLC-5: A Chloride Channel with Multiple Roles in Renal Tubular Albumin Uptake.” The International Journal of Biochemistry & Cell Biology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/16226913/.
