Anti-Centrin 1 antibody, affinity purified (rabbit polyclonal)

Anti-Centrin 1 antibody, affinity purified (rabbit polyclonal)


General information 

Description

Centrin 1 ( human; 172 aa, MW; 19,570) plays a fundamental role in microtubule organizing center structure and function. Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes. Centrins are present in the centrioles and pericentriolar lattice. Human centrin genes are CETN1, CETN2 and CETN3. Centrins are required for duplication of centrioles. They may also play a role in the severing of microtubules by causing calcium-mediated contraction.

Fig. Identification of Centrin-1 in the crude extracts of Hela cells (lane 1, 10 μg) and MCF-7 cells (lane 2, 20 μg) by Western blotting with this antibody at 1/1000 dilution.

Antigen Characterization 

• Type: Primary
• Application:  ELISA (Enzyme-Linked Immunosorbent Assay) ,Western Blot
• Species: Human
• Recombinant: Yes

• Infertility: Centrin 1 is essential for proper sperm development and function. Deficiency can lead to male infertility.
• Ciliopathies: Altered expression or mutations in Centrin 1 may contribute to ciliary dysfunction and associated disorders, such as primary ciliary dyskinesia.
• Cancer: Centrin 1 plays a role in centrosome duplication and segregation. Dysregulation may contribute to genomic instability and cancer development.
• Neurodegenerative Diseases: Centrin 1 is expressed in the brain. Changes in its expression or localization may be associated with certain neurodegenerative conditions, but more research is needed.

• Centrosome Duplication and Segregation: Centrin 1 is essential for the proper duplication and segregation of centrosomes during cell division, ensuring the formation of a bipolar mitotic spindle.
• Centriole Assembly: Centrin 1 is involved in the early stages of centriole assembly, localizing to the procentriole and regulating its formation.
• Microtubule Severing: Centrin 1 interacts with katanin, a microtubule-severing protein, and may regulate microtubule dynamics during cell division and ciliary function.
• Calcium Signaling: As a member of the EF-hand superfamily of calcium-binding proteins, Centrin 1 may play a role in calcium-mediated signaling pathways, potentially influencing cellular processes such as motility and proliferation.

Aliases for CETN1 Gene

• Centrin 1 ^2 3 5
• CEN1 ^2 3 4
• Centrin, EF-Hand Protein, 1 ^2 3
• Centrin-1 ^3 4
• CETN ^3 4
• Testicular Tissue Protein Li 37 ³
• Calcium Binding Protein ³
• Caltractin Isoform 2 ⁴
• EF-Hand Protein ³
• Caltractin ³
• CETN1 ⁵

• Salisbury JL. A mechanistic view on the evolutionary origin for centrin-based control of centriole duplication. J Cell Physiol. 213:420-8 (2007) PubMed: 17694534
• Centrin 1 Antibodies from Thermo Fisher Scientific.” Anti-Centrin 1 Antibodies | Invitrogen, 12 Feb. 2023, www.thermofisher.com/antibody/primary/target/centrin%201. 
• 12794-1-AP.” Centrin 1 Antibody (12794-1-AP) | Proteintech, 31 Aug. 2024, www.ptglab.com/products/CETN1-Antibody-12794-1-AP.htm. 
• Anti-Centrin 1 Antibody.” Abcam, www.abcam.com/en-us/products/primary-antibodies/centrin-1-antibody-ab156858. 
• CL594-12794.” Centrin 1 Antibody (CL594-12794) | Proteintech, 18 Aug. 2024, www.ptglab.com/products/Centrin-1-Antibody-CL594-12794.htm. 
• Centrin 1 Polyclonal Antibody.” Centrin 1 Polyclonal Antibody (BS-10574R), www.thermofisher.com/antibody/product/Centrin-1-Antibody-Polyclonal/BS-10574R. 
• Lab, SCBT QC, and Tomer. “Centrin-1 Antibody (2A6): SCBT - Santa Cruz Biotechnology.” SCBT, 14 Sept. 2023, www.scbt.com/p/centrin-1-antibody-2a6. 
• Centrin 1 Antibodies.” Novus Biologicals, www.novusbio.com/primary-antibodies/centrin-1.