Anti-Bilirubin Antibody (24G7)
Product#: FNK-AB01AE
$611.82
Availability:
Ships in 24 hours
Anti-Bilirubin Antibody (24G7)
General information
| Cat. No. | ：FNK-AB01AE |
| Size | ：100 µg |
| Source | ：Mouse |
| Clonality | ：Monoclonal |
| Clone name | ：24G7 |
| Purification | ：Protein G purified |
| Conjugate | ：Un-conjugated |
| Form | ：Liquid |
| Application | ：ELISA |
| Buffer | ：D-PBS(-) 80%, Glycerol 20% |
| Related products | ：Biopyrrine ELISA kits (Catalog #： BP01DE) |
Species reactivity
Anti bilirubin antibody [24G7] is recommended for detection of bilirubin of all animal species since it recognizes the chemical structure of bilirubin which is homogenous among all species. [24G7] also reacts with Biopyrrine, the metabolites of bilirubin.
Description
Bilirubin is an intermediate of heme degradation. It is an antioxidant and oxidative stress marker. Biopyrrin is the metabolites of bilirubin and an oxidative stress marker as well. Some reports suggested that oxidative stress is increased by psychological stress such as speech stress, subjective stress, social stress, and mental disorders, showing an elevated level of biopyrrin accordingly.
Antigen Characterization
- Type: Primary
- Application: ELISA, Spectrophotometry, High-Performance Liquid Chromatography (HPLC), Colorimetric Assays
- Species: Human
- Recombinant: no
- Long Term Storage: -20°C or below
- Shipping Condition: Dry ice
Human Diseases
- Jaundice: Elevated bilirubin levels lead to yellowing of the skin and eyes due to excess unconjugated or conjugated bilirubin in the bloodstream.
- Hemolytic Anemia: Increased breakdown of red blood cells results in elevated unconjugated bilirubin levels.
- Liver Diseases: Conditions such as hepatitis, cirrhosis, and biliary obstruction can impair bilirubin processing and excretion, leading to elevated levels.
- Gilbert's Syndrome: A common genetic condition characterized by intermittent episodes of elevated unconjugated bilirubin due to reduced enzyme activity.
- Crigler-Najjar Syndrome: A rare genetic disorder affecting bilirubin metabolism, leading to severe hyperbilirubinemia and jaundice."
Cellular Signaling Pathways
- Heme Catabolism: Bilirubin is produced from the breakdown of heme by heme oxygenase, which converts heme into biliverdin before it is reduced to bilirubin by biliverdin reductase.
- Conjugation Pathway: In the liver, bilirubin undergoes glucuronidation via UDP-glucuronosyltransferase (UGT1A1), making it water-soluble for excretion in bile.
- Antioxidant Activity: Bilirubin exhibits antioxidant properties, scavenging reactive oxygen species (ROS) and potentially protecting cells from oxidative stress.
- Inflammatory Response: Bilirubin can modulate inflammatory pathways and has been suggested to have protective effects against neuroinflammation.
Aliases for Bilirubin Gene
- Bilirubin IXα
- BR
- Delta bilirubin (when bound to albumin)
- Unconjugated bilirubin (indirect bilirubin)
- Conjugated bilirubin (direct bilirubin)
References
- Bilirubin | Sonic Bookings, www.sonicbookings.com.au/our-tests/elft-euc-lft/bilirubin/.
- Neonatal Hyperbilirubinemia - Neonatal Hyperbilirubinemia.” MSD Manual Professional Edition, www.msdmanuals.com/professional/pediatrics/metabolic-electrolyte-and-toxic-disorders-in-neonates/neonatal-hyperbilirubinemia.
- Bilirubin Test.” Testing.Com, 29 Nov. 2022, www.testing.com/tests/bilirubin/.
- Bilirubin Blood Test.” Mount Sinai Health System, www.mountsinai.org/health-library/tests/bilirubin-blood-test.
- Sroufe, Nicole S. “Table 4, Indications for Bilirubin Testing Modalities and Infant Jaundice Studies - Management of Indirect Neonatal Hyperbilirubinemia - NCBI Bookshelf.” Management of Indirect Neonatal Hyperbilirubinemia [Internet]., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/books/NBK567493/table/diagnostic.t1/.
- Mohammad Wehbi, MD. “Bilirubin.” Reference Range, Interpretation, Collection and Panels, Medscape, 5 Dec. 2020, emedicine.medscape.com/article/2074068-overview?form=fpf.
- Content Map Terms.” Bilirubin Test | HealthLink BC, www.healthlinkbc.ca/tests-treatments-medications/medical-tests/bilirubin.
- Yamaguchi, T., Shioji, I., Sugimoto, A., Komoda, Y., & Nakajima, H. Epitope of 24G7 anti-bilirubin monoclonal antibody.Biochimica et Biophysica Acta (BBA)-General Subjects, 1289 (1), 110-114. 1996
