(2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OH

Cat. No: FNK-CBB004


Description

• Molecular Formula : C27H35NO5Si,
• M.W.：481.66,
• Purity : >95% (HPLC),
• Optical purity : >95% ee,
• Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.

size: 200mg

Storage Condition: -20℃, Dark Storage, Keep Dry
 

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Optically Active Fmoc-Protected β-Hydroxy-α-amino Acid (Serine) Derivatives

Chiral Building Blocks for Peptide Synthesis and Drug Discovery Research


Optically active Fmoc-protected β-hydroxy-α-amino acid derivatives are highly valuable chiral building blocks for peptide and medium-sized molecule drug discovery. β-Hydroxy-α-amino acid residues are key structural motifs found in numerous peptide natural products and peptide-based therapeutics, including vancomycin. Leveraging proprietary technology developed by the Institute of Microbial Chemistry (BIKAKEN), we have successfully commercialized a unique series of non-natural serine derivatives possessing two contiguous stereogenic centers—compounds that have previously been difficult to obtain.

* Please do not hesitate to contact Diagnocine Technical support team, if you need a Structure Data Format (SDF) file and/or bulk purchase (large quantity) of the compounds.
* This product is for research use only.



The chiral building blocks are developed and supplied by proprietary technologies
from Institute of Microbial Chemistry (Bikaken).
 

Key Features

• Ready for Direct Use in Solid-Phase Peptide Synthesis (SPPS):
  These N-Fmoc-protected amino acid derivatives, the most widely used protecting group strategy for SPPS, are supplied with the side-chain hydroxyl group also protected, enabling their direct use in peptide synthesis and in the preparation of amino acid analogues and derivatives.
   
• High-Quality Chiral Reagents:
  All products meet stringent quality standards with chemical purity >95% and optical purity >95% ee, making them reliable chiral building blocks for synthetic applications.
   
• A Unique Product Line Enabled by Proprietary Catalytic Technology:
  Utilizing the highly stereoselective direct catalytic asymmetric aldol reaction¹ developed by the Institute of Microbial Chemistry (BIKAKEN), we have established a stable supply of diverse non-natural amino acid derivatives with a wide variety of side-chain structures. These products are ideal for expanding peptide drug discovery libraries and for the exploration of novel amino acid derivatives.

 

Product Table

All the compounds below are, Purity: >95% (HPLC), Optical Purity: >95% ee.
Click the compound name to view detailed information, click the product code to view the price list,
and click the chemical structure to enlarge the image.
 

Product Name	Product code	Structure	Molecular Formula	Molecular Weight	CAS No.	view page (Size: 200 mg)
(2R,3S)-Fmoc-3-cyclobutyl-Ser(TBS)-OH	FNK-CBB012		C28H37NO5Si	495.69	/
(2S,3R)-Fmoc-3-cyclobutyl-Ser(TBS)-OH	FNK-CBB011		C28H37NO5Si	495.69	/
(2R,3S)-Fmoc-3-cyclohexyl-Ser(TBS)-OH	FNK-CBB006		C30H41NO5Si	523.75	/
(2S,3R)-Fmoc-3-cyclohexyl-Ser(TBS)-OH	FNK-CBB005		C30H41NO5Si	523.75	/
(2R,3S)-Fmoc-3-cyclopentyl-Ser(TBS)-OH	FNK-CBB010		C29H39NO5Si	509.72	/
(2S,3R)-Fmoc-3-cyclopentyl-Ser(TBS)-OH	FNK-CBB009		C29H39NO5Si	509.72	/
(2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OH	FNK-CBB004		C27H35NO5Si	481.66	/	current page
(2S,3R)-Fmoc-3-cyclopropyl-Ser(TBS)-OH	FNK-CBB003		C27H35NO5Si	481.66	/
(2R,3S)-Fmoc-3-ethyl-Ser(TBS)-OH	FNK-CBB016		C26H35NO5Si	469.65	/
(2S,3R)-Fmoc-3-ethyl-Ser(TBS)-OH	FNK-CBB015		C26H35NO5Si	469.65	2382557-25-5
(2R,3S)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH	FNK-CBB002		C29H41NO5Si	511.73	/
(2S,3R)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH	FNK-CBB001		C29H41NO5Si	511.73	/
(2R,3S)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH	FNK-CBB008		C27H37NO5Si	483.68	1447759-04-7
(2S,3R)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH	FNK-CBB007		C27H37NO5Si	483.68	1379595-58-0
(2R,3S)-Fmoc-3-pentyl-Ser(TBS)-OH	FNK-CBB020		C29H41NO5Si	511.73	/
(2S,3R)-Fmoc-3-pentyl-Ser(TBS)-OH	FNK-CBB019		C29H41NO5Si	511.73	/
(2S,3R)-Fmoc-3-propyl-Ser(TBS)-OH	FNK-CBB017		C27H37NO5Si	483.68	/
(2R,3S)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH	FNK-CBB014		C29H39NO6Si	525.72	/
(2S,3R)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH	FNK-CBB013		C29H39NO6Si	525.72	/

 

Reference

1. Takeuchi, T. and Shibasaki, M., Org. Lett., 26(37), 7981(2024). [PMID:39255778]