Radicicol (100µg, 1mg, 5mg)
Cat No: BLK-0500
Monorden A, which is a macrolactone antibiotic, was isolated from Monosporium bonorden1), Cylindrocarpon radicicola 2), Penicillium luteoorantium3), and other microorganisms. Monorden A binds to Hsp90 (Heat Shock Protein 90) and alters its function4). Monorden A is known as protein kinase inhibitor. Radicicol is an antifungal antibiotic that was shown to inhibit transformation by oncogenes v-src, ras, raf, and mos5, 6).
Origin: Pochonia .sp FKI-4937
CAS Registry Number: 12772-57-5
CA Index Name: 8-Chloro-1α , 14,15,15α - tetrahydro-9,11-dihydroxy-14- methyl-6Hoxireno[e][benzoxacyclotetradecin -6,12(1H)-dione
Appearance: lemon-yellow needles
Molecular Formula/ Weight: C19H17ClO6=364.78
Melting Point: 196-197℃
Purity: >98% by HPLC
Solubility: Sol. MeOH, Chloroform, EtOAc, DMSO Inso. water, Hexane
Handling and Storage: Store at -20℃.