PIPA for TMPRSS2-ERG

Product#: HPTE08
$1.00

Size:

  • 100 ug
  • 1 mg
Availability:
Ships in 1-2 weeks

PIPA for TMPRSS2-ERG

Cat. No.
 HPTE08
Size 100ug / 1 mg

Description

From small to large scale Production
Professional expertize in peptide science, using own know-how and technologies in solid-phase syntheses, characterization and purification technologies allow production of high quality of polyamides (peptides) containing pyrrole and imidazole (PIPA).

HiPep Laboratories has been founded for industrial applications of bio-molecular recognition

PIPA_sturcture.png

PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).

PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.

Binding site specificity is dependent on the side-by-side pairing of Py and Im and gives a hairpin motif.

PIPA are generally difficult to prepare, since they may possess structures during assembly, which involves complicated reaction procedures with many steps and the characteristics of Py and Im as building blocks are not simple with respect to stability and solubility.

Features

  • Alternative gene silencer other than siRNA or PNA
  • Stable in cells or bodies because of nuclease resistance
  • Specifically binds to the target double strand DNA
  • Flexible Design against any gene
  • No-toxicities have been found in animal experiments
  • Form : Freeze dried powder
  • No additives

Code

Structure (C-terminal amide)

Mol. Weight

Target Gene

Reference

HPTB01

Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp

1787.9

Human TGF-β1

1

HPTB02

Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

Human TGF-β1

1

HPTB03

Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp

1912

Human TGF-β1

1

HPTB04

Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp

1665.78

Rat TGF-β1

2

HPLH05

Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp

1911.01

Human LOX-1

3

HPLR06

Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp

1667.75

Rat LOX-1

4

HPCT07

Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp

1912

Human CTGF

5

HPTE08

Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp

1668.74

TMPRSS2-ERG

6*

HPTE09

Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

TMPRSS2-ERG

6*

* Published patent

Gene Control Reagent : PIPA

Alternative gene silencer other than siRNA or PNA
PIPA (Py-Im-Polyamide)

Reference

  1. Igarashi, J. et. al., PLoS One. 2015,10, e0125295.
  2. Matsuda, H. et. al., Kidney Int. 2011, 79, 46-56.
  3. Kamei, T. et. al., J. Biomed. Biotechnol., 2012, 2102:715928.
  4. Yao, E. H. et. al., Hypertension, 2008, 52, 86-92.
  5. Wan, J. X.et. al., Biol. Pharm. Bull. 2011, 34, 1572-1577.
  6. Obinata, D. et. al., Cancer Sci., 2014, 105, 1272-1278.
  7. P. B. Dervan et. al., Nature (1998) 391 468-471
  8. P. B. Dervan and R. W. Burli, Current Opinion in Chemical Biology 3 (1999) 688-693
  9. P. B. Dervan, Bioorganic & Medicinal Chemistry 9 (2001) 2215-2235.

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