PIPA for Human TGF-β1

Product#: HPTB02
$1.00

Size:

  • 100 ug
  • 1 mg
Availability:
Ships in 1-2 weeks

PIPA for Human TGF-β1

Cat. No.
 HPTB02
Size 100ug /1mg

Description

PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).

PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.

HPTB01_fig1.png

Features

  • Alternative gene silencer other than siRNA or PNA
  • Stable in cells or bodies because of nuclease resistance
  • Specifically binds to the target double strand DNA
  • Flexible Design against any gene
  • No-toxicities have been found in animal experiments
  • Form : Freeze dried powder
  • No additives

Code

Structure (C-terminal amide)

Mol. Weight

Target Gene

Reference

HPTB01

Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp

1787.9

Human TGF-β1

1

HPTB02

Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

Human TGF-β1

1

HPTB03

Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp

1912

Human TGF-β1

1

HPTB04

Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp

1665.78

Rat TGF-β1

2

HPLH05

Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp

1911.01

Human LOX-1

3

HPLR06

Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp

1667.75

Rat LOX-1

4

HPCT07

Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp

1912

Human CTGF

5

HPTE08

Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp

1668.74

TMPRSS2-ERG

6*

HPTE09

Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

TMPRSS2-ERG

6*

* Published patent

Gene Control Reagent : PIPA

Alternative gene silencer other than siRNA or PNA
PIPA (Py-Im-Polyamide)

Reference

  1. Igarashi, J. et. al., PLoS One. 2015,10, e0125295.
  2. Matsuda, H. et. al., Kidney Int. 2011, 79, 46-56.
  3. Kamei, T. et. al., J. Biomed. Biotechnol., 2012, 2102:715928.
  4. Yao, E. H. et. al., Hypertension, 2008, 52, 86-92.
  5. Wan, J. X.et. al., Biol. Pharm. Bull. 2011, 34, 1572-1577.
  6. Obinata, D. et. al., Cancer Sci., 2014, 105, 1272-1278.
  7. P. B. Dervan et. al., Nature (1998) 391 468-471
  8. P. B. Dervan and R. W. Burli, Current Opinion in Chemical Biology 3 (1999) 688-693
  9. P. B. Dervan, Bioorganic & Medicinal Chemistry 9 (2001) 2215-2235.

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