Ivermectin B1a

Product#: BLS0360
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Ivermectin B1a


Cat No: BLS0360
Size 100μg

Origin: semi-synthetic
CAS Registry Number: 71827-03-9
CA Index Name: 22,23-Dihydro-5-O-demethylavermectin A1a
Appearance: white solid
Molecular Formula/ Weight: C48H74O14=875.10
Melting Point: 149-153℃
Purity:>98% by HPLC
Solubility: Sol. In MeOH, DMSO, Chloroform,EtOH, EtOAc, Acetone, AcetonitrileInsoluble in Water, Hexane


Background Information:

Ivermectin (22, 23-dihydroavermectin B1a), obtained by selective reduction with Wilkinson catalyst, improvedboth the spectrum of activity and safety7). Ivermectin is the most effective, broad-spectrum antiparasitic everdeveloped. Ivermectin was introduced to the market in 1981 as a veterinary antiparasitic drug and soonproved to be the most effective, broad-spectrum antiparasitic drug.Five years after its introduction, ivermectin was registered for use in 46 countries and being used worldwide totreat approximately 320 million cattle, 151 million sheep, 21 million horses, and 5.7 million pigs. Virtually alldogs and horses in the USA are given it.Used as an anthelmintic in animal health, in 1987 it was donated free for human use and is being distributedto eliminate River Blindness from Africa and South America. Furthermore, ivermectin is also used for thecontrol of Lymphatic filariasis, strongyloidiasis and scabies in humans8,9).

Handling and Storage:

Store at -20℃.

References:

1. R. W. Burg et al., Antimicrob. Agents Chemother., 15, 361–367 (1979).
2. Y. Takahashi et al., Int. J. Syst. Evol. Microbiol., 52, 2163-2168 (2002).
3. S. J. Danishefsky et al., J. Am. Chem. Soc., 111, 2967–2980 (1989).
4. D. F. Cully et al., J. Biol. Chem., 271, 20187–20191 (1997).
5. K. S. Todd et al., Am. J. Vet. Res., 45, 976–977 (1984).
6. A. Pomes et al., Biochim. Biophys. Acta., 1339, 233–238 (1997).
7. J. C. Chabala, H. Mrozik, R. L. Tolman, P. Eskola, A. Lusi, L. H. Peterson, M. F. Wood & M. H. Fisher, J. Med. Chem. 23, 1134-1136 (1980)
8. Taylor, H. R., and Greene, B. M. Am. J. Trop. Hyg. 41, 460-466 (1989).
9. Satoshi Õmura and Andy Crump, Nature Review, Microbiology, 12, 984-989 (2004).

Synthesized by Organic Chemistry Group, The Kitasato Institute.
(starting material, Avermevtin B1a, manufactured with Cortesy strain from The Kitasato Institute)
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