Hepatitis B Virus Surface Antigen, L-protein, Genotype A, B, C, D

Product#: BCL-AG
$923.00
Genotype
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Hepatitis B Virus Surface Antigen, L-protein, Genotype A, B, C, D (HBsAg, L-protein, Recombinant)

DiagnoCine offers excellent HBsAg | Hepatitis B Surface Antigen Antibodies  to researchers studying Hepatitis Serologic Marker, Acute Infection, Blood Tests, HBV signaling, and Diagnostic research topics. 

Human diseases include HBV infection, chronic liver cell damage, liver scarring, cirrhosis, liver cancer, acute infection-mediated clinical symptoms.

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Anti- HBsAg | Hepatitis B Surface Antigen Antibodies has excellent quality and this highly pure antibody can be adapted for Western Blots, ELISA, Immunohistochemistry, Immunofluorescence research with optimization.  

General information

Cat. No. BCL-AG
Size :100µg
Source   Saccharomyces cerevisiae
Appearance :Lyophilized white powder
Structure :Particle (L-protein inserted in lipid bilayer) with mean particle size of about 70nm by dynamic light scattering method
   (about 20 nm by electronic microscope)
Dissolve :For 100 µg vial, added 500 µL of water to the vial that makes a antigen solution at 0.2 mg/mL in PBS
   (137 mM NaCl, 8.1 mM Na2HPO4 • 12H2O, 2.68 mM KCl, 1.47 mM KH2PO4, pH 7.2 - 7.4) containing 1% sucrose.
Purity :Over 95%
Storage :-20°C (3 years guarantee after dispatch)
Usage :HBV mimetics, Standard antigen for ELISA, western, and others
*Caution :L protein may be adsorbed on plastic tubes especially low concentration (below 100ng/mL).
    Please use protein low bind tubes at lower concentration.


Introduction

HBsAg is the surface antigen of Hepatitis B virus (HBV). HBsAg is known to be present in blood if HBV infected patients, and used as a important diagnostic maker of HBV infection. HBsAg forms a small lipid particle(diameter 50 to 60nm)in which many antigen protein are present. Each antigen protein has three domains, called S, Pre-S1 and Pre-S2. L-type antigen contains all the three domains, M-type antigen contains S- and Pre-S2, and S-type antigen consisted of only S-domains. During the process of HBV infection, Pre-S1 domain plays a key role for host (hepatic) cell recognition, and Pre-S2 domain is essential for cell penetration. In infected patients, hepatic cells produces a lot of non-infectious S-type HBsAg (HBV mimetics without genome). The detection of serum Pre-S2 and Pre-S1 antigen is, therefore, very important to reveal the mechanism of HBV infection. Beacle has over a decade of R&D history on HBsAg and related materials. In this page we introduce HBsAg-related antibodies. All antibodies listed here are good for western blot and ELISA.

Description 

Hepatitis B virus (HBV) expresses three types of surface antigens, i.e. S-, M-, and L-protein. L-protein is composed of S-, Pre-S2, and Pre-S1 region. The deletion of Pre-S1 region forms M-protein and further deletion of Pre-S2 region results in S-protein. Most of commercially available HBsAg is composed of either S-protein alone or a mixture of Sand M-proteins. The Pre-S1 region is known to be the hepatic cell recognition site and to be important in the HBV infection. The present product, HBsAg, L-protein (L antigen) is a particulate antigen composed of L protein, and can be used as a tool to investigate the mechanism of HBV infection, ELISA and others. Four major genotypes of products are available.

Hepatitis B Virus Surface Antigen, L-protein, (HBsAg, L-protein, Recombinant)     

Particulate HBsAg composed of L protein that has all three (S、Pre-S1、Pre-S2) domains, also called L antigen or large S antigen. The product is produced in recombinant yeast. Because all the three domains can produce antibodies and are recognized by each domain-specific antibodies, the product is ideal as an universal antigens. In addition, the antigen can be used as a tool to investigate HBV infection. Four products with different genotypes are available; genotype A, B, C and D.
 

  Product #   Product Name   Subtype   Price ($)
  BCL-AG_A-01      HBsAg L-protein genotype A, recombinant             adw     PRICE INQUIRE 
  BCL-AG_B-01   HBsAg L-protein genotype B, recombinant    adw  PRICE INQUIRE
  BCL-AG_AGC-01    HBsAg L-protein genotype C, recombinant    adr   923.00
  BCL-AG_D-01   HBsAg L-protein genotype D, recombinant    ayw  PRICE INQUIRE
 
BCL-AG.png Fig. 1: SDS-PAGE 
HBsAg, L-protein of genotype A to D were subjected for SDS-PAGE (Silver staining) at 100ng.


Related Product

  • L 001 Hepatitis B Virus Surface Antigen (HBsAg),
  • L-protein (Recombinant) protein (Recombinant)
  • BCL-AB-001 Anti HBV Pre Anti HBV Pre Anti HBV Pre-S1 antibody,
  • mouse mono S1 antibody, mouse mono S1 antibody, mouse mono-1 


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