Anti Mouse Haao Polyclonal Antibody

Product#: KG408
$522.57
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Anti Mouse Haao Polyclonal Antibody
 

DiagnoCine offers excellent  Haao I 3-hydroxyanthranilate 3,4-dioxygenase Antibodies  to researchers studying Intellectual Neurodevelopmental Phenotypes which includes Disability & Developmental delay, Depression & Suicidal Behaviors, Neuroinflammation, Regulation Of Glutamate neurotransmission, NMDA Receptor Synthesises Cellular Senescence in aging & Hepatocytes, Seizures,  Acute Kidney Injury & Renal Ischemia, and Plant Genomic Evolution of Prasinoderma Coloniale. 
 
Human diseases include Autism Spectrum Disorders, Hypogonadism, Psychological Disorders including Clinical depression, Hypospadias, Osteoarthritis, Alzheimer's, and other Aging-related diseases.  

Anti-Haao I 3-hydroxyanthranilate 3,4-dioxygenase Antibodies have excellent quality and this highly pure antibody can be adapted for Immunohistochemistry and other experimental methods with optimization.



General information 

Cat. No. KG408
Primary Source MGI:1349444
Type Polyclonal
Concentration 0.25 mg/mL
ContentsVolume 25 μg(100 μL/vial)
Gene ID 107766
Immunogen
Partial peptide of Mouse Haao
Purification Antigen Affinity
Source Rabbit serum
Myeloma -
Clone number -
Isotype -
Buffer PBS [containing 2% Block Ace as a stabilizer,0.1% Proclin as a bacteriostat]
Cross Reactivity Not yet tested in order species
Label Unlabeled
Keyword 3HAO; 3-HAO; 3-HAOxase; 0610007K21Rik; 0610012J07Rik; Haao 3-hydroxyanthranilate 3,4-dioxygenase
Storage Store at - 20℃ long term, store at 4℃ short term. Avoid repeated freeze-thaw cycles.
Application WB,IHC
 

ELISA

WB

IHC

ICC

IP

FCM

IF

Neutralization

Not tested

Not tested

5.0-10

Not tested

Not tested

Not tested

Not tested

Not tested

                                                                                                        (µg/mL)


Description

Haao (3-hydroxyanthranilate 3,4-dioxygenase), also known as 3HAO, is a biosynthetic enzyme of quinolinic acid (QUIN). QUIN, a natural brain constituent, is a structural analogue of neurotransmitters such as L-glutamate and L-aspartate, and acts as an excitotoxin through NMDA receptors in neuron of central nervous system.

The level of 3HAO expression and QUIN are high in the brain of the El mice which are established animal model for human epilepsy, and the increased production of QUIN is secondary to an increased activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO) in the brain of these mice. In human, the activity of 3HAO is higher in the brains of patients with Huntington chorea than in control brains.


References 

  1. Nakano,K. et al.: Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice Brain Res. 1992 572 (1-2), 1-4 
  2. Eastman,C.L. et al.: Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and Epilepsy Res. glutamine synthetase in seizure-prone and non-epileptic mice 1994 18 (3), 185-194
  3. Nakagawa,Y. et al.: Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice Brain Res. 1998 Mol. Brain Res. 58 (1-2), 132-137

 

Aliases for HAAO Gene

  • 3-Hydroxyanthranilate 3,4-Dioxygenase 2 3 4 5
  • 3-Hydroxyanthranilic Acid Dioxygenase 3 4
  • 3-Hydroxyanthranilate Oxygenase 3 4
  • EC 1.13.11.6 4 51
  • 3-HAO 3 4
  • H3HAO 3 4
  • HAD 3 4
  • VCRL1 3
  • HAAO 5
  • HAO 3

 


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