Anti Mouse Fcα/μR Monoclonal Antibody (Clone No. TX61)

Product#: KO572
$586.55
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Anti Mouse Fcα/μR Monoclonal Antibody (Clone No. TX61)


General information 

Cat. No. KO572
Primary Source MGI:1927803
Type Monoclonal Antibody
Target Fcα/μR
Category Immunology
Concentration 0.25 mg/mL
ContentsVolume 50 μg(200 μL/vial)
Gene ID 64435
Immunogen
Mouse Fcα/μR expressing cell line
Purification ProteinG
Source Serum-free medium
Myeloma Sp2/0
Clone number TX61
Isotype IgG1,κ
Buffer PBS [containing 2% Block Ace as a stabilizer,0.1% Proclin as a bacteriostat]
Cross Reactivity Human/ Mouse 
Label Unlabeled
Storage Store below –20 ℃. Once thawed, store at 4 ℃. Repeated freeze-thaw cycles should be avoided.
Synonyms MGC129330; MGC129331; Fcamr
Application IP,FCM,IF
 

ELISA

WB

IHC

ICC

IP

FCM

IF

Neutralization

Not tested

Not tested

Not tested

Not tested

5.0-10

0.5-1.0

5.0-10

Not tested

                                                                                                        (µg/mL)

 

UniPlot Summary

  • Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
  • Subcellular location: Cell membrane; Single-pass type I membrane protein.
  • Tissue specificity: Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B cells and macrophages but not granulocytes, T cells or NK cells (at protein level).
  • Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
KO572_1 KO572_2.png KO572_3.png
 

References

  1. Shibuya A, et al. "Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes." Nat Immunol. 2000 Nov;1(5):441-6.
  2. Cho Y, et al. "Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR." Biochem Biophys Res Commun. 2006 Jun 23;345(1):474-8. *Application Reference
  3. Honda S, et al. "Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice." Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11230-5.

 

Aliases for FCAMR Gene

  • Fc Fragment Of IgA And IgM Receptor 2 3 5
  • High Affinity Immunoglobulin Alpha And Immunoglobulin Mu Fc Receptor 3 4
  • Fc Receptor, IgA, IgM, High Affinity 2 3
  • Fc Alpha/Mu Receptor 3 4
  • FCA/MR 2 3
  • FKSG87 2 3
  • CD351 2 3
  • Receptor For Fc Fragment Of IgA And IgM 3
  • Immunity Related Factor 3
  • CD351 Antigen 4
  • FCAMR 5

 

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