Anti Human RAGE Polyclonal Antibody

Product#: KH039
$522.57
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Anti Human RAGE Polyclonal Antibody
RAGE:Advanced Glycosylation End product-specific Receptor


General information 

Cat. No. KH039
Size 100 µg (400 µL / vial)
Clone No.  H12
Subclass IgG1
Host Animal      Rabbit
Format Rabbit polyclonal antibody 0.25mg/mL
Purification method This antibody was purified from rabbit serum by Protein G affinity chromatography.
Buffer Block Ace as a stabilizer, containing 0.1% Proclin as a bacteriostat
Application   Western blotting: 5.0µg/ml
Shipping and Storage Store below -20℃ Once thawed, store at 4℃. Repeated freeze-thaw cycles should be avoided.
 

Description

RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecular weight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been found in several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand of RAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE, N-carboxymethyllysine(CML),β-amyloid and so on.

The accumulation of AGEs-proteins in vivo has been demonstrated in several disease, it is not clear whether AGEs-proteins accumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE is involved in pathophysiological function of diabetes and Alzheimer’s disease. This antibody is affinity purified rabbit polyclonal antibody raised against partial peptide of human RAGE and should be used for western blotting.

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References

  1. Neeper M, Schmidt AM,Brett J,et al.:Cloning and expression of a cell surface receptor for advanced glycosylation end products of protein.J Biol Chem 267:14998-15004,1992
  2. Schmidt AM ,Viannaet M ,Gerlach M,et:al:Isolation and characerization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 267:14987-14997,1992
 

Aliases for AGER Gene

  • Advanced Glycosylation End-Product Specific Receptor 2 3 5
  • RAGE 2 3 4
  • Advanced Glycosylation End Product-Specific Receptor 3 4
  • SCARJ1 2 3
  • SRAGE 2 3
  • Receptor For Advanced Glycation End-Products Variant 20 3
  • Receptor For Advanced Glycosylation End Products 4
  • Receptor For Advanced Glycation End-Products 2
  • AGER 5


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