Anti Human GPR120 Monoclonal Antibody (Clone No. 2B6)

Product#: KG138
$586.55
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Anti Human GPR120 Monoclonal Antibody (Clone No. 2B6)


General information 

Cat. No. KG138
Primary Source HGNC: 19061
Type Monoclonal Antibody
Concentration 0.25 mg/mL
ContentsVolume 25 μg(100 μL/vial)
Gene ID 338557
Immunogen
Partial peptide of Human GPR120
Purification ProteinG
Source Serum-free medium
Myeloma P3UI
Clone number 2B6
Isotype IgG2aκ
Buffer PBS [containing 2% Block Ace as a stabilizer,0.1% Proclin as a bacteriostat]
Cross Reactivity Not yet tested in other species.
Label Unlabeled
Storage Store below –20 ℃. Once thawed, store at 4 ℃. Repeated freeze-thaw cycles should be avoided.
Application :FCM, ICC
 

ELISA

WB

IHC

ICC

IP

FCM

IF

Neutralization

Not tested

Not tested

Not tested

5.0

Not tested

1.0-5.0

Not tested

Not tested

                                                                                                        (µg/mL)

 

Description

GPR120 is a member of G protein-coupled receptor (GPCR) family and functions as a specific receptor for unsaturated long-chain free fatty acids (FFAs) such as palmitoleic acid, α-linolenic acid, docosahexaenoic acid. The expression of GPR120 is widely detected in various tissues, and GPR120 is highly expressed in the pituitary, lung, small intestine, colon, and adipose tissues.

It has been shown that the stimulation of GPR120 by FFAs promotes the secretion of GLP-1, known as the most potent insulinotropic incretin, from the gastrointestinal tract. It has been also demonstrated that FFAs stimulate the ERK and PI3K-Akt pathways through GPR120 and lead to anti-apoptotic effect in enteroendocrine cell line, and that GPR120 regulates adipogenic process such as adipocyte development and differentiation.

In addition, a study suggested that GPR120 is expressed in the taste bud cells in circumvallate papillae to sense dietary fat. This antibody is specific to GPR120 and will be useful for research on diabetes, obesity.

KG138_fig2.png  
Immunocytochemical staining of HEK293T cells overexpressing human GPR120


WARNING AND PRECAUTION

  1. Not for diagnostic use. The safety and efficacy of product in diagnostic or other clinical uses has not been established.
  2. Harmful by inhalation, in contact with skin and if swallowed. Do not breathe dust. Avoid contact with skin and eyes.
  3. If contact with skin and eyes, wash all affected areas with large volume of water. If inhaled remove to fresh air. In severe case obtain medical attention.
  4. Wash hand thoroughly after handling the product.
  5. Do not use this product if container is broken or some contaminants are detected.
  6. When preserving the product, Close the container, ensure it does not fall aside or down.
  7. Dispose of the container and expired reagents in accordance with federal, state and local government regulations.
  8. Do not use the container and accessories of the product for other purpose. 


References 

  1. Gotoh C. et al.:The regulation of adipogenesis through GPR120.
  2. Matsumura S. et al.: GPR expression in the rat taste bud relating to fatty acid sensing.
  3. KatsumaS.et al: Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.
  4. Hirasawa A. et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.

 

Aliases for FFAR4 Gene

  • Free Fatty Acid Receptor 4 2 3 4 5
  • Omega-3 Fatty Acid Receptor 1 2 3 4
  • PGR4 2 3 4
  • G-Protein Coupled Receptor GT01 3 4
  • G-Protein Coupled Receptor PGR4 3 4
  • G-Protein Coupled Receptor 120 3 4
  • G-Protein Coupled Receptor 129 3 4
  • GPR120 3 4
  • GPR129 3 4
  • O3FAR1 3 4
  • G Protein-Coupled Receptor 129 2
  • G Protein-Coupled Receptor 120 2
  • BMIQ10 3
  • FFAR4 5
  • GT01 3

 


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