Anti Human CD98hc(4F2) Monoclonal Antibody (Clone No.WK4)

Product#: KS129
$586.55
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Anti Human CD98hc(4F2) Monoclonal Antibody (Clone No.WK4)


General information 

Cat. No. :KS129
Primary Source HGNC:11026
Type Monoclonal
Concentration 0.25 mg/mL
ContentsVolume 50 µg (200 µL/vial)
Gene ID -
Immunogen
Human Cancer Cell Line
Purification ProteinG
Source Serum-free medium
Myeloma P3UI
Clone number WK4
Isotype IgG2a, κ
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Cross Reactivity Not yet tested in other species.
Label Unlabeled
Storage Store below –20 ℃. Once thawed, store at 4 ℃. Repeated freeze-thaw cycles should be avoided.
Application :FCM, IP
 

ELISA

WB

IHC

ICC

IP

FCM

IF

Neutralization

Not tested

Not tested

Not tested

Not tested

5.0-10.0

0.5-1.0

Not tested

Not tested

                                                                                                        (µg/mL)

 

Description


CD98hc is highly expressed on proliferating lymphocytes, tumor cells and on the other rapidly-growing cells. It has also shown that CD98hc has an important role in integrin-dependent signals that promote tumorigenesis. This antibody is specific to human CD98hc and will be useful for FCM, immunoprecipitation.

It is thought that the heavy chain is mainly involved in the trafficking of the complex to the plasma membrane, whereas the light chain catalyses the transport itself. CD98hc is a multifunctional glycoprotein, and was originally discovered as a T-cell activation antigen.

CD98 (also known as 4F2) is widely expressed cell surface around 120-kDa heterodimetric protein. CD98 is composed a common type II transmembrane heavy chain of around 80-kDa (also kwon as CD98hc, 4F2hc or SLC3A2) and one of at least six light chains of around 40-kDa (LAT1, LAT2, y+LAT1, y+LAT2, xCT, asc) to form amino acid transporters.


References

  1. Nakamura E. et al.: 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem. 1999 Jan 29;274(5):3009-16. 
  2. Nii T. et al.: Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during Tcell activation. Biochem J. 2001 Sep 15;358(Pt 3):693-704.
  3. Fenczik CA. et al.: Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem. 2001 Mar 23;276(12):8746-52. Epub 2000 Dec 19. 
  4. Henderson NC. et al.: CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem. 2004 Dec 24;279(52):54731-41. Epub 2004 Oct 12. 
  5. Feral CC. et al.: CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):355-60. Epub 2004 Dec 29. 


Warning and Precaution

  1. Not for diagnostic use. The safety and efficacy of product in diagnostic or other clinical uses has not been established.
  2. Harmful by inhalation, in contact with skin and if swallowed. Do not breathe dust. Avoid contact with skin and eyes.
  3. If contact with skin and eyes, wash all affected areas with large volume of water. If inhaled remove to fresh air. In severe case obtain medical attention.
  4. Wash hand thoroughly after handling the product.
  5. Do not use this product if container is broken or some contaminants are detected.
  6. When preserving the product, Close the container, ensure it does not fall aside or down.
  7. Dispose of the container and expired reagents in accordance with federal, state and local government regulations.
  8. Do not use the container and accessories of the product for other purpose. 

 

Aliases for SLC3A2 Gene

  • Solute Carrier Family 3 Member 2 2 3 4 5
  • Lymphocyte Activation Antigen 4F2 Large Subunit 2 3 4
  • 4F2 Cell-Surface Antigen Heavy Chain 2 3 4
  • Solute Carrier Family 3 (Activators Of Dibasic And Neutral Amino Acid Transport), Member 2 2 3
  • Antigen Identified By Monoclonal Antibodies 4F2, TRA1.10, TROP4, And T43 2 3
  • Solute Carrier Family 3 (Amino Acid Transporter Heavy Chain), Member 2 2 3
  • Monoclonal Antibody 44D7 2 3
  • CD98 Heavy Chain 2 3
  • CD98HC 2 3
  • 4F2HC 2 3
  • 4T2HC 2 3
  • NACAE 2 3
  • CD98 2 3
  • MDU1 3 4
  • 4F2 2 3
  • Antigen Defined By Monoclonal Antibody 4F2, Heavy Chain 3
  • Antigen Defined By Monoclonal Antibody 4F2 2
  • 4F2 Heavy Chain Antigen 4
  • 4F2 Heavy Chain 2
  • CD98 Antigen 4
  • Heavy Chain 2
  • SLC3A2 5
  • 4F2hc 4

 

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